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The molecular basis of association mechanism between Alzheimer's disease and tooth loss

Research Project

Project/Area Number 23659900
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionHiroshima University

Principal Investigator

AKAGAWA Yasumasa  広島大学, 大学院・医歯薬学総合研究院, 教授 (00127599)

Co-Investigator(Kenkyū-buntansha) MICHIKAWA Makoto  名古屋市立大学, 大学院・医学研究科, 教授 (40270912)
宮本 泰成  広島大学, 医歯薬保健学研究院, 助教 (00555146)
Co-Investigator(Renkei-kenkyūsha) MIYAMOTO Yasunari  広島大学, 大学院・医歯薬学総合研究院, 助教 (00555146)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯の喪失 / アルツハイマー病 / アミロイドβ / ステップスルー型受動的回避試験 / 歯・咬合の喪失
Research Abstract

To elucidate the association between tooth loss and Alzheimer ’ s disease, we compared tooth extracted group with tooth intact group using Alzheimer ’ s model mice. As a result, we found that tooth loss did not influence the accumulation of Aβ. However, the number of pyramidal cell of tooth extracted group is decreased compared with tooth intact group. And, the results of behavioral test revealed that tooth loss deteriorates the learning and memory ability. We could suggest that tooth loss affect the AD pathogenesis or AD onset through another pathway of well-known amyloid cascade.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2013 Other

All Presentation (3 results)

  • [Presentation] Tooth loss induces memory impairment and neuronal cell loss2013

    • Author(s)
      Oue Hiroshi, Yasunari Miyamoto, Shinsuke Okada, Katsunori Koretake, Yasumasa Akagawa
    • Organizer
      91th IADR
    • Place of Presentation
      Seattle U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Tooth loss induces neuronal cell loss in APP transgenic mice2013

    • Author(s)
      大上博史
    • Organizer
      IADR
    • Place of Presentation
      Seattle(アメリカ)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー病と歯の喪失・咬合関連メカニズム

    • Author(s)
      大上博史
    • Organizer
      認知症研究を知る若手研究者の集まり
    • Place of Presentation
      愛知県
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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