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Serum-free medium for dental regenerative tissue engineering

Research Project

Project/Area Number 23659918
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dental engineering/Regenerative dentistry
Research InstitutionHiroshima University

Principal Investigator

KATO Yukio  広島大学, 医歯薬学総合研究科, 教授 (10112062)

Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords血清 / 幹細胞 / 無血清培地 / 歯 / 再生
Research Abstract

Ex vivo expansion and differentiation of dental epithelial cells and dental mesenchymal cells are required for tooth regeneration. We developed serum-free medium of dental pulp cells, and this many facillital development of dental tissue enginnering.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (21 results)

All 2012 2011

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (7 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] BHLH transcription factor DEC2 regulates pro-apoptotic actor Bim in human oral cancer HSC-3 cells2012

    • Author(s)
      Wu Y, Sato F, Sato H, Jin D, BhawalUK, Wu Y, Noshiro M, Kawamoto T, Fujimoto K, Seino H, Morohashi S, Kato Y, Kijima H
    • Journal Title

      Biomedical Research

      Volume: 33(2)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver2012

    • Author(s)
      Sato, F., Wu, Y., Noshiro, M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Issue: 2 Pages: 441-446

    • DOI

      10.1016/j.bbrc.2012.02.076

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of basic helix-loop-helix transcription factors Dec1 and Dec2 by RORα and their roles in adipogenesis.2012

    • Author(s)
      Ozaki N
    • Journal Title

      Genes to Cells

      Volume: 17 Issue: 2 Pages: 107-121

    • DOI

      10.1111/j.1365-2443.2011.01574.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver Corresponding2012

    • Author(s)
      Sato F, et al
    • Journal Title

      BBRC

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells2012

    • Author(s)
      Wu Y, et al
    • Journal Title

      Biomedical Research

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility and limitations of the round robin test for assessment of in vitro chondrogenesis evaluation protocol in a tissue-engineered medical product2011

    • Author(s)
      Masako Yokoi, et al.
    • Journal Title

      JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

      Volume: (掲載確定)(印刷中)) Issue: 7 Pages: 550-558

    • DOI

      10.1002/term.460

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of synthetic octacalcium phosphate in a collagen scaffold on the osteogenicity of mesenchymal stem cells2011

    • Author(s)
      Kawai T., Anada T., Masuda T., Honda Y., Sakai Y., Kato Y., Kamakura S., Echigo S., Suzuki O
    • Journal Title

      European Cells and Materials

      Volume: 22 Pages: 124-136

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of Zinc Fingers and Homeoboxes 3 (ZHX3) on the Regulation of Mesenchymal Stem Cell Osteogenic Differentiation2011

    • Author(s)
      Suehiro F, Nishimura M, Kawamoto T, Kanawa M, Yoshizawa Y, Murata H, Kato Y
    • Journal Title

      Stem Cells Develop

      Volume: 20(9) Issue: 9 Pages: 1539-1547

    • DOI

      10.1089/scd.2010.0279

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cell-induced cranial suture-like gap in rats2011

    • Author(s)
      Kaku M, Tai M, Kawata T, Fujita T, Motokawa M, Ohtani J, Sakai Y, Kato Y, Tanne K
    • Journal Title

      Plast Reconstr Surg

      Volume: 127(1) Issue: 1 Pages: 69-77

    • DOI

      10.1097/prs.0b013e3181f95849

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells.2011

    • Author(s)
      Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, Morohashi S, Kato Y, Kijima H
    • Journal Title

      Eur J Cancer

      Volume: 47(11) Issue: 11 Pages: 1747-58

    • DOI

      10.1016/j.ejca.2011.02.025

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells2011

    • Author(s)
      Wu, Y., Sato, F., Kawamoto, T., Fujimoto, K., Noshiro, M., (他4名)
    • Journal Title

      Int J Mol Med

      Volume: 27 Issue: 4 Pages: 491-495

    • DOI

      10.3892/ijmm.2011.617

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin D1. Bhawal2011

    • Author(s)
      U.K., Sato, F., Arakawa, Y., Fujimoto, K., Kawamoto, T., Tanimoto, K., Ito, Y., Sasahira, T., Sakurai, T., Kobayashi, M., Kashima, I., Kijima, H., Kuniyasu, H., Abiko, Y., Kato, Y., Sato, S
    • Journal Title

      J. Pathol

      Volume: 224(3) Issue: 3 Pages: 420-429

    • DOI

      10.1002/path.2878

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Serum-Free Cultures for Human Mesenchymal Stem Cells using Defined Culture Surfaces. 1st Meeting of Surabaya Regenerative Medicine and Stem Cell Centre(SRMSC)2011

    • Author(s)
      Yukio Kato
    • Organizer
      2nd Meeting of Indonesia Association of Tissue Bank(IATB), SYMPOSIUM
    • Place of Presentation
      Surabaya, Indonesia
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞表面抗原を指標とした口腔内からの骨前駆細胞の分取2011

    • Author(s)
      鎌田浩一、藤本勝巳、西村正宏、末廣史雄、貞森紳丞、赤川安正、加藤幸夫
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 間葉系幹細胞の軟骨分化におけるDEC2の役割2011

    • Author(s)
      笹本智子、藤本勝巳、金輪真佐美、河本健、能城光秀、道田将彦、尾崎徳継、丹根一夫、加藤幸夫
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 間葉系幹細胞の増殖・分化ならびにインテクリン発現に対する転写因子GATA6の作用2011

    • Author(s)
      道田将彦、河本健、能城光秀、藤本勝巳、金輪真佐美、尾崎徳継、笹本智子、丹根一夫、加藤幸夫
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 核内受容体RORαによる時計遺伝子DEC1, DEC2の発現調節と脂肪分化2011

    • Author(s)
      尾崎徳継、能城光秀、河本健、福崎麗、藤本勝巳、丹根一夫、加藤幸夫
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Related Report
      2011 Final Research Report
  • [Presentation] Serum-Free Cultures for Human Mesenchymal Stem Cells using Defined Culture Surfaces2011

    • Author(s)
      Yukio Kato
    • Organizer
      1^<st> Meeting of Surabaya Regenerative Medicine and Stem Cell Centre (SRMSC), 2^<nd> Meeting of Indonesia Association of Tissue Bank (IATB), SYMPOSIUM
    • Place of Presentation
      Surabaya, Indonesia(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核内受容体RORαによる時計遺伝子DEC1,DEC2の発現調節と脂肪分化2011

    • Author(s)
      尾崎徳継, 他
    • Organizer
      第52回日本生化学会中国・四国支部例会
    • Place of Presentation
      広島市
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 動物細胞培養キット、動物細胞の培養方法及び動物細胞の選択培養方法2012

    • Inventor(s)
      加藤幸夫、平田伊佐雄、金輪真佐美
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      2011-084119
    • Filing Date
      2012-04-05
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 間葉系幹細胞の均質性識別方法、その方法を利用して得られる均質間葉系幹細胞2012

    • Inventor(s)
      加藤幸夫、金輪真佐美、五十嵐晃、原真依子、辻紘一郎
    • Industrial Property Rights Holder
      広島大学、(株)ツーセル
    • Acquisition Date
      2012-03-30
    • Related Report
      2011 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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