Evaluation of distribution and state for the eluted metal elements in the living body and the cells
| Project/Area Number |
23659931
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UO Motohiro 東京医科歯科大学, 医歯薬学総合研究科, 教授 (20242042)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 溶出金属 / 溶出金属元素 / 蛍光XAFS法 / 生体材料 |
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| Research Abstract |
Four dental alloy were implanted in subcutaneous of animal. Migraition into the surrounding tissue of the alloy component elements analyzed by using a suitable radiation XRF for the detection of trace elements, and alloy element distribution in the surrounding tissue was visualized.
In the non-noble metal addition silver alloy with low anti-corrosion, Ag and Sn was observed in the surrounding tissue. In cobalt and gold-silver palladium alloy with high anti-corrosion, localization of alloy component elements was confirmed.
It was found that most of the alloying component elements in the tissue were a hydration ion state, the eluted hydration ion or the eluted ion as sulfide (Ag), oxide (Cr) by using the XAFS measurement that can identify the chemical state of the alloy component elements.
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Report
(4 results)
Research Products
(2 results)
