| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
Fucci transgenic mice constitutively expressing cell-cycle probes are important tools to analyze the spatiotemporal transition of the cell-cycles in periodontium, especially, are useful to visualize the cell-cycles of undifferentiated mesenchymal cells and gingival epithelial cells. The molecular imaging employing Fucci technology demonstrated that a series of active enzymes produced by neutrophil during periodontal inflammation would induce G1-arrest of the cell-cycle of periodontal cells.
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