Comprehensive understanding of neurodegeneration and brain tumor by focusing on cell cycle

• Project/Area Number: 23680032
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: AJIOKA Itsuki 東京医科歯科大学, 脳統合機能研究センター, 准教授 (10348790)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000); Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: Rb / 大脳皮質発生 / 癌 / 神経変性疾患

Research Abstract

We found that the acute inactivation of Rb family (Rb, p107, p130) in cortical progenitors leads differentiating neurons to undergo cell division, while that in differentiating neurons leads them to undergo cell death. We also found that the uncoupled neuronal differentiation and proliferation of Rb family-deficient cortical cells required the activation of DNA repair pathway.

Research Products

• [Journal Article] Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner. (2013)
  • Author(s): Oshikawa M, Okada K, Nakajima K, Ajioka I
  • Journal Title: Development Volume: 140(11) Issue: 11 Pages: 2310-20
  • DOI: 10.1242/dev.095653
  • Peer Reviewed
• [Journal Article] Basement membrane-like matrix sponge for the three-dimensional proliferation culture of differentiated retinal horizontal interneurons (2011)
  • Author(s): Ajioka I, Ichinose S, Nakajima K, Mizusawa H
  • Journal Title: Biomaterials Volume: 32 Issue: 25 Pages: 5765-5772
  • DOI: 10.1016/j.biomaterials.2011.04.062
  • Peer Reviewed
• [Presentation] 神経発生学の知見を活かした傷害脳再生への試み (2013)
  • Author(s): 味岡逸樹
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 横浜(シンポジスト)
• [Presentation] 神経発生学の知見を活かした傷害脳再生への試み (2013)
  • Author(s): 味岡逸樹
  • Organizer: 第12回日本再生医療学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] The role of Rb family for cell cycle exit and migration during cerebral cortical development (2012)
  • Author(s): Itsuki Ajioka
  • Organizer: The 11th Biennial Meeting of the Asia-Pacific Society for Neurochemistry/ The 55th Annual Meeting of the J apanese Society for Neurochemistry
  • Place of Presentation: Kobe, Japan(シンポジウムオーガナイザー)
• [Presentation] The role of Rb family for cell cycle exit and migration during cerebral cortical development (2012)
  • Author(s): 味岡逸樹
  • Organizer: The 11th Biennial Meeting of the Asia-Pacific Society for Neurochemistry
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 大脳皮質前駆細胞の細胞周期離脱と分化の協調がRbファミリーによって制御されている (2011)
  • Author(s): 味岡逸樹、押川未央、岡田桂
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
  • Year and Date: 2011-09-28
• [Remarks]
  • URL: http://www.tmd.ac.jp/med/cbir/ajioka.html