Retinal neuroprotection by transscleral multi-drug delivery
Project/Area Number |
23680054
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Tohoku University |
Principal Investigator |
NAGAI Nobuhiro 東北大学, 医学(系)研究科(研究院), 助教 (30400039)
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Co-Investigator(Renkei-kenkyūsha) |
ABE Toshiaki 東北大学, 大学院医学系研究科, 教授 (90191858)
KAJI Hirokazu 東北大学, 大学院工学研究科, 准教授 (70431525)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥25,870,000 (Direct Cost: ¥19,900,000、Indirect Cost: ¥5,970,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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Keywords | 薬物伝達システム / ドラッグデリバリーシステム / 網膜疾患 / 経強膜 / 神経保護 / 網膜 / ドラッグデリバリー / 強膜 / 徐放 / 網膜色素変性 / 加齢黄班変性 / デバイス |
Research Abstract |
We develped a polymeric device for multi-drug transscleral-delivery to the retina at independently controlled release rates. The device comprises a microfabricated reservoir, controlled-release cover, and drug formulations, which were made of photopolymeized tri(ethyleneglycol)dimethacrylate (TEGDM) and poly(ethyleneglycol)dimethacrylate (PEGDM). The release rate of each drug is controlled by varying the PEGDM/TEGDM ratio in its formulation. When the devices containing three different fluorescents were implanted onto rat sclerae, fluorescence was observable in the ocular tissues during 4 weeks implantation. The device when simultaneously releasing two drugs, edaravone (EDV) and unoprostone (UNO), with controlled release manner precluded the reductions of electroretinographic amplitudes, retinal thickness, and the number of apoptotic cells after light exposure in rats, suggesting that co-delivery of EDV and UNO attenuates light-induced retinal damage morphologically and functionally.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] A Platform for Controlled Dual-Drug Delivery to the Retina : Protective Effects against Light-Induced Retinal Damage in Rats2014
Author(s)
N Nagai, H Kaji, H Onami, Y Katsukura, Y Ishikawa, ZK Nezhad, K Sampei, S Iwata, S Ito, M Nishizawa, T Nakazawa, N Osumi, Y Mashima, T Abe
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Journal Title
Advanced Healthcare Materials
Volume: in press
Issue: 10
Pages: 680-687
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vasohibin-1 and retinal pigment epithelium2012
Author(s)
Yumi Ishikawa, Nobuhiro Nagai, Hideyuki Onami, Norihiro Kumasaka, Ryosuke Wakusawa, Hikaru Sonoda, Yasufumi Sato, Toshiaki Abe
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Journal Title
Adv Exp Med Biol
Volume: 723
Pages: 305-310
DOI
ISBN
9781461406303, 9781461406310
Related Report
Peer Reviewed
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[Presentation] Protective Effects of Transscleral Drug Delivery Device Against Photoreceptor Cell Death in S334ter Rhodopsin Mutant Rats2013
Author(s)
N Nagai, H Kaji, H Onami, T Yamada, Y Katsukura, Y Ishikawa, M Nishizawa, Y Mashima, T Abe
Organizer
2013 ARVO annual meeting, Seattle
Place of Presentation
Washington, USA
Related Report
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[Presentation] Protective Effects of Transscleral Drug Delivery Device Against Photoreceptor Cell Death in S334ter Rhodopsin Mutant Rats2013
Author(s)
Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Takuya Yamada, Yuki Katsukura, Yumi Ishikawa, Matsuhiko Nishizawa, Yukihiko Mashima, Toshiaki Abe
Organizer
2013 ARVO annual meeting
Place of Presentation
Seattle, Washington, USA
Related Report
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[Presentation] Protective Effects of Transscleral Drug Delivery Device Against Light-induced Retinal Damage in Rats2012
Author(s)
N Nagai, H Onami, H Kaji, T Yamada, Y Katsukura, M Sato, Y Ishikawa, T Nakazawa, M Nishizawa, T Abe
Organizer
2012 ARVO annual meeting
Place of Presentation
Fort Lauderdale, Florida, USA
Related Report
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[Presentation] Suppression of Rat Choroidal Neovascularization by Transscleral Vasohibin-1 Delivery Device2012
Author(s)
H Onami, N Nagai, R Wakusawa , H Kaji, T Yamada, Y Ishikawa, M Nishizawa, Y Sato, T Nakazawa, T Abe
Organizer
2012 ARVO annual meeting
Place of Presentation
Fort Lauderdale, Florida, USA
Related Report
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