| Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Research Abstract |
To clarify the physiological role of melatonin, we developed melatonin-proficient, N-acetylserotonin (NAS; a precursor of melatonin)-proficient, and both-deficient B6 congenic mice. We examined the circadian rhythm-related behaviors in these mice and found no significant difference. Further, there is no dramatic differences in the life span was found in these mice. In behavioral analysis, we detected several significant difference in NAS+ mice, in particular; such as short immobility time in the tail suspension test and worse memory retention. It is possible to be explained by our immunohistochemical data showing enhanced neurogenesis in NAS+ mice.
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