Physiological significance of melatonin and its precursor in mammals
Project/Area Number |
23687010
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Animal physiology/Animal behavior
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
KASAHARA Takaoki 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー (50344031)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥27,820,000 (Direct Cost: ¥21,400,000、Indirect Cost: ¥6,420,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
|
Keywords | メラトニン / マウス / アセチルセロトニン / 松果体 / AANAT / HIOMT / コンジェニック化 / 概日リズム / 光周性 |
Research Abstract |
To clarify the physiological role of melatonin, we developed melatonin-proficient, N-acetylserotonin (NAS; a precursor of melatonin)-proficient, and both-deficient B6 congenic mice. We examined the circadian rhythm-related behaviors in these mice and found no significant difference. Further, there is no dramatic differences in the life span was found in these mice. In behavioral analysis, we detected several significant difference in NAS+ mice, in particular; such as short immobility time in the tail suspension test and worse memory retention. It is possible to be explained by our immunohistochemical data showing enhanced neurogenesis in NAS+ mice.
|
Report
(4 results)
Research Products
(18 results)
-
[Journal Article]2013
Author(s)
笠原和起
-
Journal Title
松果体.分子精神医学
Volume: 13
Pages: 212-217
URL
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Sequencing of mouse pseudoautosomal region2011
Author(s)
Takaoki Kasahara, Kuniya Abe, Tadafumi Kato
Organizer
International Mammalian Genome Society、Complex Trait Consortium, The Genetics Society of Americaの合同総会(Mouse Genetics 2011)
Place of Presentation
ワシントンDC(米国)
Year and Date
2011-06-24
Related Report
-
-
-
-
-
-