| Project/Area Number |
23689005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
OINUMA Izumi 京都大学, 生命科学研究科, 助教 (40452297)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 低分子量G蛋白質 / 軸索ガイダンス / semaphorin / Plexin / R-Ras / アクチン細胞骨格 / integrin / plexin / Live-Cell Imaging / 全反射顕微鏡 / 低分子量Gタンパク質 / 神経細胞 / 成長円錐 / インテグリン |
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| Research Abstract |
R-Ras is a member of the Ras family of small GTPases, and it mediates inside-out activation of integrins and plays a central role in positive-feedback between cell adhesion and integrin activation. On the other hand, the repulsive guidance molecule semaphorin receptor, Plexin functions as a GTPase-activating protein for R-Ras, inducing inactivation of R-Ras. The seama-Plex pathway blocks the positive-feedback, inducing efficient integrin inactivation and loss of cell adhesion. However, precise molecular mechanism remain unclear. In this project, we identified some molecules which function upstream and downstream of R-Ras.
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