Targeting dendritic cell subsets with glycosylated antigens for cancer immunotherapy
| Project/Area Number |
23689009
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Juntendo University (2014-2015)
St. Luke's College of Nursing (2013)
The University of Tokyo (2011-2012) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥16,232,190 (Direct Cost: ¥12,486,300、Indirect Cost: ¥3,745,890)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,052,190 (Direct Cost: ¥3,886,300、Indirect Cost: ¥1,165,890)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
|
|---|
| Keywords | 樹状細胞 / レクチン / 糖鎖 / がんワクチン / ターゲティング / 抗腫瘍ワクチン |
|---|
| Outline of Final Research Achievements |
MUC1 antigens with glycans having a high affinity to mouse macrophage galactose-type C-type lectins expressed on a dermal dendritic subset were prepared for vaccination. Anti-MUC1 serum antibody response was significantly higher in mice immunized with glycosylated MUC1 as compared with MUC1 without glycosylation. The growth and metastasis of mouse colon carcinoma cells expressing MUC1 were suppressed by vaccination with the glycosylated MUC1. These results are suggested to be applicable in designing a novel cancer vaccine.
|
Report
(5 results)
Research Products
(30 results)
