Effects of Circadian NAD+ oscillation on the onset of age-related diseases
Project/Area Number |
23689013
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
NAKAHATA Yasukazu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50390810)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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Keywords | NAD代謝 / 概日時計 / 細胞老化 / NAD+代謝 / 代謝 |
Outline of Final Research Achievements |
In this study, we found that circadian machinery is not affected by high intracellular NAD+ at cellular and systemic levels, on the other hand, low intracellular NAD+ prolongs the period of circadian clock at the cellular level. Transgenic mice with high Nampt/NAD+ in the whole body did not show any improvements or deteriorations on glucose/lipid homeostasis. Primary MEF cells with high Nampt/NAD+ showed the delay onset of cellular senescence. These results suggest that intracellular NAD+ level in cells is associated with the maintenance of circadian clock and the onset of cellular senescence.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Sassone-Corsi P.Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT12013
Author(s)
Bellet MM, Nakahata Y, Boudjelal M,Watts E, Mossakowska DE, Edwards KA,Cervantes M, Astarita G, Loh C, Ellis JL,Vlasuk GP
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Journal Title
Proc. Natl. Acad. Sci.USA
Volume: 110
Issue: 9
Pages: 3333-3338
DOI
Related Report
Peer Reviewed
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