Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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Outline of Final Research Achievements |
In this study, we found that circadian machinery is not affected by high intracellular NAD+ at cellular and systemic levels, on the other hand, low intracellular NAD+ prolongs the period of circadian clock at the cellular level. Transgenic mice with high Nampt/NAD+ in the whole body did not show any improvements or deteriorations on glucose/lipid homeostasis. Primary MEF cells with high Nampt/NAD+ showed the delay onset of cellular senescence. These results suggest that intracellular NAD+ level in cells is associated with the maintenance of circadian clock and the onset of cellular senescence.
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