| Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Research Abstract |
Hyperphosphatemia is contributes to vascular calcification in patients with chronic kidney disease and hemodialysis patients and is associated with cardiac mortality. Recently, several studies reported the relationship among salivary phosphate concentration, renal function, serum phosphate concentration, and the potential target of new therapy for hypephosphatemia. However, it is unclear the inorganic phosphate (Pi) handling mechanisms in salivary glands. In the present study, we investigated the Pi handling in salivary glands. In wild-type mice fed a high Pi diet, the levels of plasma and salivary Pi are significantly higher than those in mice fed a low Pi diet. In Npt2b+/- mice, the salivary Pi concentrations were significantly increased compared with those in Npt2b+/+ mice. The present study suggests that salivary Pi levels correlate with dietary Pi content, and salivary glands paly a role for phosphate homeostasis system in the body.
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