| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Research Abstract |
Plasma adiponectin levels are reduced in obesity, which causes insulin resistance and type 2 diabetes. In skeletal muscle, AdipoR1 is predominantly expressed and activates AMPK and PPARgamma coactivator (PGC)-1alpha as well as calcium signalling pathways, which have also been shown to be activated by exercise. So, we proposed to identify the novel intracellular signal transduction pathways activated by AdipoR1 in the skeletal muscle and the liver.
We have elucidated the physiological and pathophysiological roles of adiponectin/AdipoR1 in the liver. Moreover, we identified the candidate key molecules relevant to exercise and AdipoR1 signaling pathways in the skeletal muscle, and clarified the gluconeogenesis mechanism regulated by AdipoR1 in the liver.
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