Identification of Novel Intracellular Signal Transduction Pathways Activated by AdipoR1 in the skeletal muscle and the liver
| Project/Area Number |
23689048
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
IWABU Masato 東京大学, 医学部附属病院, 特任助教 (30557236)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Keywords | 代謝学 / メタボリックシンドローム / アディポネクチン / アディポネクチン受容体 |
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| Research Abstract |
Plasma adiponectin levels are reduced in obesity, which causes insulin resistance and type 2 diabetes. In skeletal muscle, AdipoR1 is predominantly expressed and activates AMPK and PPARgamma coactivator (PGC)-1alpha as well as calcium signalling pathways, which have also been shown to be activated by exercise. So, we proposed to identify the novel intracellular signal transduction pathways activated by AdipoR1 in the skeletal muscle and the liver.
We have elucidated the physiological and pathophysiological roles of adiponectin/AdipoR1 in the liver. Moreover, we identified the candidate key molecules relevant to exercise and AdipoR1 signaling pathways in the skeletal muscle, and clarified the gluconeogenesis mechanism regulated by AdipoR1 in the liver.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.2013
Author(s)
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S and Kadowaki T.
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Journal Title
Nature
Volume: 503
Pages: 493-498
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.2012
Author(s)
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K,..., Okada-Iwabu M, Iwabu M, Shojima N,..., Nakamura Y, Kadowaki T
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Journal Title
Hum Mol Genet.
Volume: 21
Pages: 3042-2049
DOI
Related Report
Peer Reviewed
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[Journal Article] Global Mapping of Cell-Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte Differentiation2011
Author(s)
Waki H, Nakamura M, Yamauchi T,Wakabayashi K, Yu J, Hirose-Yotsuya L,Take K, Sun W, Iwabu M, Okada-Iwabu M,Fujita T, Aoyama T, Tsutsumi S, Ueki K,Kodama T, Sakai J, Aburatani H, Kadowaki T
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Journal Title
PLoS genetics
Volume: 7(10)
DOI
Related Report
Peer Reviewed
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[Journal Article] Structural basis for compound C inhibition of the human AMP-activated protein kinaseα2 subunit kinase domain2011
Author(s)
Handa N, Takagi T, Saijo S, Kishishita S, Takaya D, Toyama M, Terada T, Shirouzu M, Suzuki A, Lee S, Yamauchi T, Okada-Iwabu M, Iwabu M, Kadowaki T, Minokoshi Y, Yokoyam S
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Journal Title
Acta Crystallogr D BiolCrystallogr.
Volume: 67
Pages: 480-487
DOI
Related Report
Peer Reviewed
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[Presentation] Adiponectin/AdipoR1 Regulate PGC-1alpha and Mitochondria by Ca and AMPK/SIRT1 in Skeletal Muscle, Leading to Amelioration of Obese Diabetes, Like Exercise2011
Author(s)
MASATO IWABU, TOSHIMASA YAMAUCHI, MIKI IWABU, NAOTO KUBOTA, KOHJIRO UEKI, TAKASHI KADOWAKI
Organizer
American Diabetes Association, 71st Scientific Sessions
Place of Presentation
SAN DIEGO, CA, USA
Year and Date
2011-06-25
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