Examination of the molecular/cellular mechanism(s) of onset of schizophrenia

• Project/Area Number: 23689055
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: HAYASHI Akiko (TAKAGI Akiko) 東京大学, 大学院・医学系研究科, 助教 (60415271)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: 統合失調症 / 発症メカニズム / DISC1 / カルシニューリン / 樹状突起スパイン / ドーパミン

Research Abstract

in vivo dendritic spine imaging throughout late neurodevelopment of schizophrenia model mice (prefrontal specific DISC1 knockdown mice and forebrain specific Calcineurin knockout mice) was performed. We observed the progressive spine deterioration during development of these two model mice. We also identified a small molecular compound that prevents the spine deterioration, suggesting a new strategy for drug development of schizophrenia.

Research Products

• [Journal Article] グルタミン酸作動性シナプスと統合失調症 (2013)
  • Author(s): 林(高木)朗子
  • Journal Title: 神経化学 Volume: 52 Pages: 5-12
• [Journal Article] シナプスダイナミクスと統合失調症 (2012)
  • Author(s): 前田義智、舘野博宣、河西春郎、林(高木)朗子
  • Journal Title: 分子精神医学 Volume: 12 Pages: 180-188
• [Journal Article] Re addressing synaptic pruning theory for schiz ophrenia. (2011)
  • Author(s): Hayashi-Takagi A, Barker PB, Sawa A.
  • Journal Title: Commun Integr Biol Volume: vol4 Pages: 211-212
• [Journal Article] Gene expression analysis in lymphoblastoid c ells as a potential biomarker of bipolar disor der. (2011)
  • Author(s): Kato T, Hayashi-Takagi A
  • Journal Title: J Hum Genet. Volume: vol56 Pages: 779-783
  • Peer Reviewed
• [Journal Article] 光遺伝学 (2011)
  • Author(s): 林(高木)朗子、河西春郎
  • Journal Title: 分子精神医学 Volume: 1 Pages: 41-43
• [Journal Article] Readdressing synaptic pruning theory for schizophrenia (2011)
  • Author(s): Hayashi-Takagi A, Barker PB, Sawa A
  • Journal Title: Commun Integr Biol Volume: 4 Pages: 211-212
• [Journal Article] Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder (2011)
  • Author(s): Kato T, Hayashi-Takagi A, 以後3名略
  • Journal Title: J Hum Genet Volume: 56 Pages: 779-783
  • Peer Reviewed
• [Journal Article] DISC1-dependent switch from progenitor proliferation to migration in the developing cortex (2011)
  • Author(s): Ishizuka K, 11名略, Hayashi-Takagi A, 以後5名略
  • Journal Title: Nature Volume: 473 Pages: 92-96
  • Peer Reviewed
• [Journal Article] DISC1-dependent switch from pr ogenitor proliferation to migration in the dev eloping cortex.
  • Author(s): Ishizuka K, (11名略), Hayashi-Takagi A
  • Journal Title: Nature Volume: Vol473 Pages: 92-96
  • Peer Reviewed
• [Presentation] 「グルタミン酸シグナルとSynaptic protection」シンポジウム (2012)
  • Organizer: 第42回日本神経精神薬理学会
  • Year and Date: 2012-10-19
• [Presentation] 精神疾患マイクロエンドフェノタイプとしての樹状突起スパインの解析サテライトシンポジウム (2012)
  • Organizer: 第35回日本神経科学会
  • Year and Date: 2012-09-19
• [Presentation] 「DISConnectivity by DISC1: Hyper-glutamatergic condition as a possible trigger of schizophrenia? シンポジウム (2011)
  • Organizer: 第34回日本神経科学会
  • Year and Date: 2011-09-15
• [Presentation] DISConnectivity by DISC1 (Disrupted in schizophrenia 1) (2011)
  • Author(s): 林(高木)朗子
  • Organizer: 第34回日本神経科学会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] 統合失調症の病態研究から創薬への展開」シンポジウム (2011)
  • Organizer: 第33回日本生
  • Year and Date: 2011-05-22
• [Presentation] 統合失調症の病態研究から創薬への展開 (2011)
  • Author(s): 林(高木)朗子
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: ホテルグランパシフィックル ダイバ(東京都)(招待講演)
  • Year and Date: 2011-05-22
• [Book] 「分子精神医学」光遺伝学 (2011)
  • Author(s): 林(高木)朗子、河西春郎
  • Publisher: 先端医学社
• [Remarks]
  • URL: http://www.bm2.m.u-tokyo.ac.jp/hayashi/