Genetic analysis of physiological function of Rac1 and Cdc42 in dendritic spines
| Project/Area Number |
23700368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 遺伝子操作マウス / Rac1 / Cdc42 / 神経細胞 / 大脳皮質 / 細胞骨格 / mTOR |
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| Research Abstract |
In this study, I focused on analysis of neuronal functions of Rho family GTPase, Rac1 and Cdc42. We adopted analyses using both region-specific knockout mice and brain slice culture, and revealed that Rac1 is involved in the regulation of spine formation and/or morphogenesis in the cerebral cortex andhippocampus. These results may provide insights into human diseases such as mental retardation.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Cdc42 isrequired for chondrogenesis and interdigital programmed cell death during limb development.2012
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
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Journal Title
Mech. Dev
Volume: 129
Pages: 38-50
Related Report
Peer Reviewed
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[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development.2012
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
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Journal Title
Mech Dev l2012
Volume: (In press)
Pages: 320128-50
DOI
Related Report
Peer Reviewed
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