Role of DISC1 in primary cilia-mediated adult neurogenesis

Research Project

Project/Area Number	23700380
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neuroscience in general
Research Institution	Nagoya City University (2012) Osaka University (2011)
Principal Investigator	KUMAMOTO Natsuko 名古屋市立大学, 大学院・医学研究科, 講師 (30467584)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	DISC1 / 統合失調症 / 神経新生 / プライマリーシリア
Research Abstract	DISC1 knockdown using onco-retrovirus-mediated approach to genetically label and manipulate neural stem cells in adult mouse hippocampus resulted in defective primary cilia formation in vivo. Loss-of- function mutations of β-catenin in newborn neurons reversed the accelerated neuronal migration and dendritic development caused by the DISC1 knockdown.

Report

(3 results)