Molecular basis for development of topographic cortico-basal ganglia circuit

• Project/Area Number: 23700411
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: 沖縄科学技術大学院大学
• Principal Investigator: HOSHINA Naosuke 沖縄科学技術大学院大学, 細胞シグナルユ ニット, 研究員 (60598514)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Tadashi 沖縄科学技術大学院大学, 細胞シグナルユ ニット, 教授 (40134621) ; NAKAZAWA Takanobu 東京大学, 医学系研究科, 特任講師 (00447335) ; KANO Masanobu 東京大学, 医学系研究科, 教授 (40185963) ; WATANABE Masahiko 北海道大学, 医学系研究科, 教授 (70210945) ; KOBAYASHI Kazuto 福島県立医科大学, 医学部, 教授 (90211903) ; TAKADA Masahiko 京都大学, 霊長類研究所, 教授 (00236233)
• Research Collaborator: HIRANO Shinji 高知大学, 医歯学系, 准教授 (80222248)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 分子神経生物学 / 大脳基底核 / 神経回路 / シナプス / 分子生物学

Research Abstract

Highly topographic organization of neural circuits exists for the regulation of various brain functions in cortico-basal ganglia circuits. We show that protocadherin 17 (PCDH17), one of the non-clustered δ2-protocadherin family members, is enriched along cortico-basal ganglia synapses in a topographic manner, and regulates synaptic development in these synapses. Furthermore, PCDH17 knockout mice exhibit antidepressant-like phenotypes.

Research Products

• [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits. (2013)
  • Author(s): Naosuke Hoshina, Asami Tanimura, Miwako Yamasaki, Takeshi Inoue, Ryoji Fukabori Teiko Kuroda, Kazumasa Yokoyama, Tohru Tezuka, Hiroshi Sagara, Shinji Hirano, Hiroshi Kiyonari, Masahiko Takada, Kazuto Kobayashi, Masahiko Watanabe, Masanobu Kano, Takanobu Nakazawa, Tadashi Yamamoto
  • Journal Title: Neuron Volume: 78 Pages: 839-854
  • Peer Reviewed
• [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits (2013)
  • Author(s): Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
  • Journal Title: Neuron Volume: 78(5) Issue: 5 Pages: 839-854
  • DOI: 10.1016/j.neuron.2013.03.031
  • Peer Reviewed
• [Presentation] A role of protocadherin 17 in presynaptic assembly of cortico-basal ganglia circuit neurons (2011)
  • Author(s): 星名直祐
  • Organizer: 第34回日本分子生物学会年会(BMB 2011)
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] A role of protocadhA role of protocadherin 17 in presynaptic assembly in presynaptic assembly (2011)
  • Author(s): 星名 直祐
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Remarks] 星名直祐、山本雅、プロトカドヘリン17は大脳皮質-大脳基底核神経回路において前シナプスの構築を制御する、ライフサイエンス新着論文レビュー、2013年6月12日
  • URL: http://first.lifesciencedb.jp/archives/7248