| Project/Area Number |
23700422
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO Mikako 名古屋大学, 医学(系)研究科(研究院), 助教 (60444402)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 重症筋無力症 / MuSK / Collagen Q / LRP4 / 筋・末梢神経疾患 / 国際研究者交流 / パリ / アセチルコリンエステラーゼ |
|---|
| Research Abstract |
Myasthenia Gravis (MG) is antoimmuno disease caused by an antoantibody to protein consisting of neuromuscular junction. Anti MuSK MG account for fifteen percent of MG ,but it is unclear well. MuSK is membrane transfer protein of NMJ, and has Ig1, Ig2, Ig3, Ig4 and C6 box in extracellar region. In this study, it was demonstrated that anti-MuSK antibody from five persons inhibit both MuSK-ColQ and MuSK-LRP4 interaction. Moreover, MuSK antibody recognizes Ig1 and Ig4, and LRP4 also binds Ig1 and Ig4.
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