| Project/Area Number |
23700425
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
TANABE Chiaki 岩手医科大学, 薬学部, 助教 (00552902)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 老化性痴呆疾患 / アルツハイマー病 / γセクレターゼ / ERAD / synoviolin / Rer1 / アミロイドβ |
|---|
| Research Abstract |
Alzheimer ’s disease (AD) is characterized by the deposition of A・, which is generated by ・-secretase . We previously reported that synoviolin and/orHerp, which are involved in ER -associated degradation (ERAD), enhance A・generation,but the mechanism is unknown. In this study, we clarified that Syn regulates the assembly of the ・-secretase complex via the degradation of Rer1, which results in the generation of A・.
|
