| Project/Area Number |
23700434
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SHIBUYA Norihiro 独立行政法人国立精神・神経医療研究センター, 神経研究所 神経薬理研究部, 室長 (40466214)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 認知症 / 硫化水素 / 剖検脳 / アルツハイマー型認知症 / L-システイン / 過硫化型 / D-システイン / DAO / 3MST / アルツハイマー |
|---|
| Research Abstract |
Hydrogen sulfide (H2S) has been recognized as a neuromodulator as well as a cytoprotectant. Recent evidences from in vitro studies has raised the possibility that H2S is used for treatment for alzheimer’s disease. The levels of bound sulfane sulfur, a storage form of H2S, in Alzheimer disease type change (ADC) and pathological senile change (PSC) were comparable to those in minimal senile change. Although the expression of H2S-producing enzymes was unchanged in ADC and PSC, sulfur dioxygenase, a H2S-metabolizing enzyme, was increased in PSC. These observations suggest that H2S has a therapeutic potential for alzheimer’s disease.
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