Slitrk5 knock-out mice showed elevated anxiety and depression like behavior.

• Project/Area Number: 23700457
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: MATSUMOTO Yoshifumi 独立行政法人理化学研究所, 行動発達障害研究チーム, 研究員 (60513463)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: SLITRK / 不安障害 / 気分障害 / Slitrkファミリー / 神経 / LRR / SLITRKファミリー / 海馬 / シナプトジェネシス

Research Abstract

Slitrk family is strongly associated with the psychiatric disorder or auditory function. However, Slitrk5 function has not been known yet. We therefor generated Slitrk5 knockout (KO) mouse and performed comprehensive behavioral tests. Slitrk5 KO mice showed the increased anxiety and depression like behavior, and moreover showed significantly decreased serotonin levels in hippocampus among various brain regions. Taken together with these results, Slitrk5 is strongly associated with pathogenesis of anxiety and depression disorder through impairment of serotonin concentration in hippocampus.

Research Products

• [Journal Article] 3 SLITRK6 mutations cause myopia and deafness in humans and mice (2013)
  • Author(s): Mustafa Tekin, Barry A. Chioza, Yoshifumi Matsumoto, Oscar Diaz-Horta, Harold E. Cross, Duygu Duman, Haris Kokotas, Heather L. Moore-Barton, Kazuto Sakoori, Maya Ota, Yuri S. Odaka, Joseph Foster II, F. Basak Cengiz, Suna Tokgoz-Yilmaz, Oya Tekeli, Maria Grigoriadou, Michael B. Petersen, Ajith Sreekantan-Nair, Kay Gurtz, Xia-Juan Xia, Arti Pandya, Michael A. Patton, Juan. Young, Jun Aruga, and Andrew H. Crosby
  • Journal Title: The Journal of Clinical Investigation 2013 Volume: Volume 123 Number 5 Pages: 2094-102
  • Peer Reviewed
• [Journal Article] SLITRK6 mutations cause myopia and deafness in humans and mice (2013)
  • Author(s): Mustafa Tekin
  • Journal Title: The Journal of Clinical Investigation Volume: 124 Issue: 5 Pages: 1-9
  • DOI: 10.1172/jci65853
  • Peer Reviewed
• [Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTP・trans-synaptic interaction (2012)
  • Author(s): Takahashi H., Katayama K., Sohya K., Miyamoto H., Prasad T., Matsumoto Y., Ota M., Yasuda H., Tsumoto T., Aruga J and Craig AM
  • Journal Title: Nat Neurosci Volume: 15(3) Pages: 389-98
  • Peer Reviewed
• [Journal Article] LRR シナプスオーガナイザーと神経疾患 (2012)
  • Author(s): 有賀純、松本圭史
  • Journal Title: in vivo実験医学によるヒト疾患解明の最前線 Volume: vol. 30 No2 Pages: 218-223
• [Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction (2012)
  • Author(s): Hideto Takahashi, Kei-ichi Katayama, Kazuhiro Sohya, Hiroyuki Miyamoto, Tuhina Prasad, Yoshifumi Matsumoto, Maya Ota, Hiroki Yasuda, Tadaharu Tsumoto, Jun Aruga, Ann Marie Craig
  • Journal Title: Nature Neuroscience Volume: 15 Issue: 3 Pages: 389-398
  • DOI: 10.1038/nn.3040
  • Peer Reviewed
• [Journal Article] LRRシナプスオーガナイザーと神経疾患 (2012)
  • Author(s): 有賀純, 松本圭史
  • Journal Title: 実験医学 Volume: 増刊165 Pages: 218-223
• [Journal Article] Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice (2011)
  • Author(s): Matsumoto Y., Katayama K., Okamoto T., Yamada K., Takashima N., Nagao S., Aruga J.
  • Journal Title: PLoS One Volume: 26 ; 6(1)
  • Peer Reviewed
• [Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN (2011)
  • Author(s): Matsumoto Y., Takashima N., Nozaki Y., Nishioka N., Kudoh M., Aruga J
  • Organizer: Society for Neuroscience meeting 2011
  • Place of Presentation: Washington D.C., USA
• [Presentation] Slitrk6 欠損マウスの聴覚および前庭機能異常について (2011)
  • Author(s): 松本圭史、片山圭一、岡本武人、山田一之、永雄総一、工藤雅治、 有賀純
  • Organizer: 第34回日本神経科学大会、パシフィコ横浜
  • Place of Presentation: 横浜
• [Presentation] Slitrk6欠損マウスの聴覚および前庭機能異常について (2011)
  • Author(s): 松本圭史
  • Organizer: 日本神経科学会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Zic2 knock down mice show the higher response to auditory stimulus and size reduction of DCoN. (2011)
  • Author(s): Y. MATSUMOTO
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC (USA)
• [Book] in vivo実験医学によるヒト疾患解明の最前線 (2012)
  • Author(s): 有賀純
  • Total Pages: 6
  • Publisher: 羊土社
• [Remarks] 理化学研究所・脳科学総合研究センター・行動発達障害研究チーム
  • URL: http://lcn.brain.riken.jp/topicsj.html