Slitrk5 knock-out mice showed elevated anxiety and depression like behavior.
Project/Area Number |
23700457
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
MATSUMOTO Yoshifumi 独立行政法人理化学研究所, 行動発達障害研究チーム, 研究員 (60513463)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | SLITRK / 不安障害 / 気分障害 / Slitrkファミリー / 神経 / LRR / SLITRKファミリー / 海馬 / シナプトジェネシス |
Research Abstract |
Slitrk family is strongly associated with the psychiatric disorder or auditory function. However, Slitrk5 function has not been known yet. We therefor generated Slitrk5 knockout (KO) mouse and performed comprehensive behavioral tests. Slitrk5 KO mice showed the increased anxiety and depression like behavior, and moreover showed significantly decreased serotonin levels in hippocampus among various brain regions. Taken together with these results, Slitrk5 is strongly associated with pathogenesis of anxiety and depression disorder through impairment of serotonin concentration in hippocampus.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] 3 SLITRK6 mutations cause myopia and deafness in humans and mice2013
Author(s)
Mustafa Tekin, Barry A. Chioza, Yoshifumi Matsumoto, Oscar Diaz-Horta, Harold E. Cross, Duygu Duman, Haris Kokotas, Heather L. Moore-Barton, Kazuto Sakoori, Maya Ota, Yuri S. Odaka, Joseph Foster II, F. Basak Cengiz, Suna Tokgoz-Yilmaz, Oya Tekeli, Maria Grigoriadou, Michael B. Petersen, Ajith Sreekantan-Nair, Kay Gurtz, Xia-Juan Xia, Arti Pandya, Michael A. Patton, Juan. Young, Jun Aruga, and Andrew H. Crosby
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Journal Title
The Journal of Clinical Investigation 2013
Volume: Volume 123 Number 5
Pages: 2094-102
Related Report
Peer Reviewed
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[Journal Article] Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction2012
Author(s)
Hideto Takahashi, Kei-ichi Katayama, Kazuhiro Sohya, Hiroyuki Miyamoto, Tuhina Prasad, Yoshifumi Matsumoto, Maya Ota, Hiroki Yasuda, Tadaharu Tsumoto, Jun Aruga, Ann Marie Craig
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Journal Title
Nature Neuroscience
Volume: 15
Issue: 3
Pages: 389-398
DOI
Related Report
Peer Reviewed
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