Developmental changes in Ca channel density and single channel conductance at the presynaptic terminal of central nervous system
| Project/Area Number |
23700474
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ニューロン / シナプス / 神経回路 / プレシナプス / カルシウムチャネル / 脳・神経 / 神経科学 / Caチャネル / 生理学 / 共焦点顕微鏡 / 国際研究者交流 / シナプス伝達 / シナプス前末端 |
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| Research Abstract |
Using patch-clamp technique and Ca2+-imaging, I investigated the number and conductance of voltage-gated Ca2+ channels expressed in the giant presynaptic nerve terminal calyx of Held in the auditory brainstem. The estimated single channel conductance was ~2 pS and its local density at release site ~250/μm ^2, both of which remain unchanged during the postnatal development across hearing onset. Throughout this period, multiple Ca2+ channels make a cluster. The distance between Ca2+ channels and release machinery for neurotransmitter is estimated as 30-50 nm
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Report
(3 results)
Research Products
(14 results)
