Cardiac stem cells therapy for myocardial infarction using novel hydrogel

• Project/Area Number: 23700485
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Juntendo University
• Principal Investigator: MATSUSHITA Satoshi 順天堂大学, 医学部, 准教授 (20407315)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心筋機能不全 / 再生 / 再生医療 / 幹細胞治療 / 心筋梗塞 / GFP陽性ラット / 心筋幹細胞 / 細胞治療 / ハイドロゲル / 細胞残存率 / 心機能評価表

Research Abstract

Cardiac stem cells derived from GFP-positive rat heart were conjugated into thermo sensitive novel hydrogel (Hg), then injected into the rat hearts with myocardial infarction. Greater improvement of heart function was seen in the rat with hydrogel administration compared to the rat with cells alone at four weeks. Histological analysis demonstrated that the injected cells were more retained in the hydrogel group, with increasing expression of cardiac marker and vascular marker proteins in the heart.