Analysis of the physiology of mitochondrial morphology control by MARCH-V

• Project/Area Number: 23700517
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Gunma University (2012); The Institute of Physical and Chemical Research (2011)
• Principal Investigator: GOTO Eiji 群馬大学, 生体調節研究所, 助教 (40435649)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ミトコンドリア / ユビキチン / 胎生致死 / E3ユビキチンリガーゼ

Research Abstract

In this study, by using the MARCH-V knockout mice, I demonstrated that mice lacking MARCH-V die after embryonic day 10.5. Moreover, histological studies revealed that loss of MARCH-V led to proliferative abnormality of neuroepithelial cells.

Research Products

• [Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation (2012)
  • Author(s): Tokunaga F, Nishimasu H, Ishitani R, Goto E, Noguchi T, Mio K, Kamei K, Ma A, Iwai K, Nureki O
  • Journal Title: EMBO J. Volume: 31 Issue: 19 Pages: 3856-3870
  • DOI: 10.1038/emboj.2012.241
  • Peer Reviewed
• [Journal Article] Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. (2012)
  • Author(s): Kensche, T.
  • Journal Title: J. Biol. Chem. Volume: 287 Issue: 28 Pages: 23626-23634
  • DOI: 10.1074/jbc.m112.347195
  • Peer Reviewed
• [Journal Article] The inter-transmembrane region of KSHV MIR2 contributes to B7-2 downregulation. (2012)
  • Author(s): Kajikawa, M.
  • Journal Title: J. Virol. Volume: 86 Issue: 9 Pages: 5288-5296
  • DOI: 10.1128/jvi.00219-12
  • Peer Reviewed
• [Journal Article] The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane (2012)
  • Author(s): Tanno, H.
  • Journal Title: Mol.Biol.Cell Volume: 23 Issue: 7 Pages: 1343-1353
  • DOI: 10.1091/mbc.e11-09-0817
  • Peer Reviewed
• [Presentation] 新規ユビキチン結合因子Ankrd13によるエンドサイトーシス制御 (2011)
  • Author(s): 丹野秀崇、山口鉄平、後藤栄治、石戸聡、駒田雅之
  • Organizer: 第84回日本生化学会大会・シンポジウム-拡大するユビキチンバイオロジー
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-23