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Alveolar kinematics and gas exchange mechanism in chronic pulmonarydiseases

Research Project

Project/Area Number 23700549
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

SERA Toshihiro  大阪大学, 臨床医工学融合研究教育センター, 特任講師(常勤) (40373526)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords末梢気道 / 慢性閉塞性肺疾患 / 数値計算 / 放射光 / 肺胞 / 動態解析 / 気流シミュレーション / 国際情報交流 / シミュレーション
Research Abstract

In this study, we analyzed the acinar kinematics of healthy and chronic obstructive pulmonary diseases (COPD) using synchrotron based computed tomography, and numerical simulation of mass transport in pulmonary acinus. Under quasi-static inflation, in healthy mice, the duct diameter increased at early phase of inspiration. The increase rate in COPD mice was smaller than healthy mice. We investigated the airflow in healthy and COPD acinar model reconstructed from synchrotron CT. Not only the velocity but also the difference between inspiratory and expiratory flow were smaller in COPD mice than healthy mice, indicating that the gasexchange performance might become worse in COPD.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Book (2 results)

  • [Journal Article] A semi-automatic segmentation algorithm for extracting pulmonary microstructures of acini from synchrotron micro-CT images2013

    • Author(s)
      Luosha Xiao, Toshihiro Sera, Kenichiro Koshiyama, ShigeoWada
    • Journal Title

      Computational and Mathematical Methods in Medicine volume

      Volume: 2013 Pages: 10-10

    • DOI

      10.1155/2013/575086

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo2013

    • Author(s)
      Toshihiro Sera, Hideo Yokota, Kentaro Uesugi, Naoto Yagi
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 185 Issue: 3 Pages: 639-646

    • DOI

      10.1016/j.resp.2012.12.002

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Murine pulmonary acinar mechanics during quasi-static inflation using synchrotron refraction-enhanced CT2012

    • Author(s)
      Toshihiro Sera, Hideo Yokota, Gaku Tanaka, Kentaro Uesugi, Naoto Yagi, Robert C Schroter
    • Journal Title

      Journal of Applied Physiology

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高分解能 in vivo-CTの開発と気道末梢部位の気流シミュレーション2012

    • Author(s)
      世良俊博、横田秀夫,上杉健太朗、八木直人
    • Journal Title

      電子情報通信学会技術研究報告, 医用画像

      Volume: 111(331) Pages: 43-48

    • NAID

      10031092894

    • Related Report
      2012 Final Research Report
  • [Journal Article] Kinematic irreversibility of oscillatory flow in expanding and contracting small airways2012

    • Author(s)
      Gaku Tanaka, Masayoshi Ohgawara, Genri Inagaki, Makoto Hishida, Toshihiro Sera
    • Journal Title

      International Journal of Heat and Mass Transfer

      Volume: 55 Issue: 7-8 Pages: 1873-1880

    • DOI

      10.1016/j.ijheatmasstransfer.2011.11.040

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synchrotron Refraction Enhanced Tomography of an Intact Common Marmoset (Callithrix jacchus)2012

    • Author(s)
      Toshihiro Sera, Hideo Yokota, Sakiko Nakamura, Kentaro Uesugi, Masato Hoshino, Naoto Yagi, Toshio Ito, Keigo Hikishim, Hirotaka James Okano
    • Journal Title

      Open Journal of Radiology

      Volume: 1 Issue: 02 Pages: 28-37

    • DOI

      10.4236/ojrad.2011.12005

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 肺動態解析による肺気腫診断の可能性に関する技術2013

    • Author(s)
      東良亮、世良俊博、内藤尚、松本健志、田中正夫
    • Organizer
      第21回バイオフィジオロジー研究会
    • Place of Presentation
      京都
    • Year and Date
      2013-02-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Semi-automatic segmentation method to extract multiple pulmonary acini from synchrotron micro-CT images2013

    • Author(s)
      Rosa Shaw, Toshihiro Sera, Kenichiro Koshiyama, Shigeo Wada
    • Organizer
      第21回バイオフィジオロジー研究会
    • Place of Presentation
      京都
    • Year and Date
      2013-02-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺動態解析による肺気腫診断の可能性に関する技術2013

    • Author(s)
      東良亮、世良俊博、内藤尚、松本健志、田中正夫
    • Organizer
      第21回バイオフィジオロジー研究会
    • Place of Presentation
      ホテル京阪京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Semi-automatic segmentation method to extract multiple pulmonary acini from synchrotron micro-CT images2013

    • Author(s)
      Rosa Shaw, Toshihiro Sera, Kenichiro Koshiyama, Shigeo Wada
    • Organizer
      第21回バイオフィジオロジー研究会
    • Place of Presentation
      ホテル京阪京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺細葉動態解析のための放射光屈折コントラストCT、2012

    • Author(s)
      世良俊博、横田秀夫、田中学、上杉健太朗、八木直人
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Numerical simulation of alveolar flow and particle deposition in alveolar region2011

    • Author(s)
      Toshihiro SERA
    • Organizer
      Bioengineering 11
    • Place of Presentation
      ロンドン
    • Year and Date
      2011-09-13
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 慢性閉塞性肺疾患時における肺の3次元動態解析

    • Author(s)
      東良亮
    • Organizer
      関西学生会平成23年度学生員卒業研究発表講演会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Book] 生物流体力学2012

    • Author(s)
      谷下一夫、山口隆美
    • Total Pages
      247
    • Publisher
      朝倉書店
    • Related Report
      2011 Research-status Report
  • [Book] 肺呼吸の流れ2011

    • Author(s)
      世良俊博
    • Publisher
      朝倉書店
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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