Novel liver fibrosis treatment with nano-complexes of apoptosis inducing factor and gelatin derivatives

• Project/Area Number: 23700560
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyoto University
• Principal Investigator: UESUGI Yoshiko 京都大学, 再生医科学研究所, 特定研究員 (30416416)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナノドラッグデリバリーシステム

Research Abstract

The cirrhosis is a chronic disease that is caused by hepatic damages with virus infection, alcohol, and drug, is leading causes of hepatic fibrosis and deterioration of liver functions. However, there are no available treatments despite the implantation of the liver. This study is undertaken to prepare a novel cirrhosis treatment system with nano-complexes of apoptosis inducing factor (TRAIL: tumor necrosis factor-related apoptosis-inducing ligand) and gelatin derivatives which targeting hepatic stellate cells based on the mechanism of cirrhosis.