Elucidation of the rehabilitation effects on nitric oxide factors in metabolic syndrome model

• Project/Area Number: 23700593
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: ITO Daisuke 東北大学, 病院, 理学療法士 (50466570)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: リハビリテーション / メタボリックシンドローム / 一酸化窒素 / 運動療法 / 循環器・高血圧 / 蛋白質

Research Abstract

I examine the effects of the exercise training on nitric oxide (NO) system in metabolic syndrome model of rats. Exercise improved insulin resistance, and tended to increase the expression of endothelial nitric oxide synthase (eNOS) and neuronal NOS (nNOS) in left ventricle and kidney of rats. These findings suggest that the upregulation of the renal NO system may be a novel mechanism that could explain thebeneficial effects of exercise training.

Research Products

• [Journal Article] Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats (2013)
  • Author(s): Ito D, Ito O, Cao P, Mori N, Suda T, Muroya Y, Takashima K, Ito S, Kohzuki M
  • Journal Title: Clin Exp Pharma Physiol Volume: 40 Issue: 2 Pages: 74-82
  • DOI: 10.1111/1440-1681.12040
  • Peer Reviewed
• [Journal Article] 慢性心不全モデルラットにおける長期的運動の心・腎一酸化窒素合成酵素に対する影響 (2012)
  • Author(s): 伊藤大亮,伊藤修,森信芳,須田千尋,羽尾清貴,曹鵬宇,戎栄,下川宏明,上月正博
  • Journal Title: 日本心不全学会NewsLetter Volume: 16 Pages: 19-22
• [Journal Article] Disorders of fatty acid metabolism in the kidney of puromycin aminonucleosideinduced nephrotic rats (2012)
  • Author(s): Muroya Y, Ito O, Rong R, Takashima K, Ito D, Cao P, Nakamura Y, Joh K, Kohzuki M
  • Journal Title: Am J Physiol Renal Physiol Volume: 303 Issue: 7 Pages: F1070-F1079
  • DOI: 10.1152/ajprenal.00365.2011
  • Peer Reviewed
• [Journal Article] 慢性心不全モデルラットにおける長期的運動の心・腎一酸化窒素合成酵素に対する影響 (2012)
  • Author(s): 伊藤大亮，伊藤 修，森 信芳, 須田千尋，羽尾清貴，曹 鵬宇，戎 栄，下川宏明，上月正博
  • Journal Title: 日本心不全学会News Letter Volume: 16 Pages: 19-22
• [Journal Article] PANネフローゼラットにおける腎内脂肪酸代謝異常に対する clofibrate と valsartanの治療効果 (2012)
  • Author(s): 室谷嘉一，伊藤 修，戎 栄, 高島健太，曹 鵬宇, 伊藤大亮，上月正博
  • Journal Title: Therapeutic Research Volume: 33 Pages: 170-172
  • Peer Reviewed
• [Presentation] 慢性心不全ラットにおける長期的運動の心・腎一酸化窒素合成酵素に対する影響 (2012)
  • Author(s): 伊藤大亮,伊藤修,森信芳,須田千尋,羽尾清貴,曹鵬宇,戎栄,下川宏明,上月正博
  • Organizer: 第16回日本心不全学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-11-30
• [Presentation] Effects of exercise training on nitric oxide synthases expression and phosphorylation in the kidney of spontaneously hypertensive rats (2012)
  • Author(s): Ito D, Ito O, Cao P, Mori N, Suda C, Muroya Y, Takashima K, Kohzuki M
  • Organizer: 24th Scientific Meeting of International Society of Hypertension
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-09-30
• [Presentation] 長期的運動が慢性心不全ラットの心・腎一酸化窒素合成酵素に及ぼす影響 (2012)
  • Author(s): 伊藤大亮,伊藤修,森信芳,須田千尋,羽尾清貴,曹鵬宇,戎栄,下川宏明,上月正博
  • Organizer: 第18回日本心臓リハビリテーション学会
  • Place of Presentation: さいたま
  • Year and Date: 2012-07-13
• [Presentation] 腎NO系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮,伊藤修,曹鵬宇,森信芳,室谷喜一,高島健太,上月正博
  • Organizer: 第12回日本NO学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-06-29
• [Presentation] 血圧と腎Nitric oxide系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮,伊藤修,曹鵬宇,森信芳,上月正博
  • Organizer: 第47回日本理学療法学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-05-25
• [Presentation] 腎nitri coxide系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮,伊藤修,曹鵬宇,森信芳,須田千尋,室谷喜一,高島健太,上月正博
  • Organizer: 第2回日本腎臓リハビリテーション学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-01-21
• [Presentation] 長期的運動が慢性心不全ラットの心・腎一酸化窒素合成酵素に及ぼす影響 (2012)
  • Author(s): 伊藤大亮，伊藤 修，森 信芳，須田千尋, 羽尾清貴, 曹 鵬宇, 戎 栄，下川宏明，上月正博
  • Organizer: 第18回日本心臓リハビリテーション学会
  • Place of Presentation: 大宮
• [Presentation] 血圧と腎Nitric oxide 系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮，伊藤 修，曹 鵬宇, 森 信芳, 上月正博
  • Organizer: 第47回日本理学療法学会
  • Place of Presentation: 神戸
• [Presentation] 腎nitric oxide 系に対する長期的運動の影響 (2012)
  • Author(s): 伊藤大亮
  • Organizer: 日本腎臓リハビリテーション学会 第2回学術大会
  • Place of Presentation: 仙台市
• [Presentation] Exercise training increases nitric oxide synthases in the kidney of rats with chronic heart failure (2011)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
  • Organizer: American Heart Association High Blood Pressure Research 2011Scientific Sessions
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-09-21
• [Presentation] Disability prevention of cardiovascular and chronic kidney diseases: Effects of exercise training on nitric oxide synthases in rats with chronic heart failure (2011)
  • Author(s): Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
  • Organizer: 6th World Congress of the International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2011-06-12
• [Presentation] Effects of exercise on NOS in rats with CHF (2011)
  • Author(s): Ito D
  • Organizer: International Society of Physic and Reha
  • Place of Presentation: Puerto Rico
• [Presentation] Exercise increases NOS in the kidney of rats (2011)
  • Author(s): Ito D
  • Organizer: AHA High Blood Pressure Research 2011
  • Place of Presentation: Orlando, アメリカ