• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Association of genetic polymorphisms and lifestyle factors with postprandial autonomic nervous response and gastric motility

Research Project

Project/Area Number 23700831
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionKyoto University

Principal Investigator

MATSUNAGA Tetsuro  京都大学, 人間・環境学研究科, 技術補佐員 (10452286)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords自律神経 / 胃運動 / 胃電図 / 遺伝子多型 / 食習慣 / 心拍変動 / 食事
Research Abstract

Hypofunction of autonomic nervous system and gastric motility is closely related to cardiovascular and metabolic diseases and functional gastric disorder, respectively. This study investigated the association of genetic polymorphisms (ghrelin, growth hormone secretagogue receptor, cholecystokinin receptor, and G-proten β3 subunit(GNB3)) and lifestyle factors (physical activity and dietary habit) with postprandial autonomic nervous response and gastric motility using heart rate variability analysis and electrogastrography in young healthy subjects. The present study showed that body mass index, blood pressure, and polymorphisms in ghrelin and GNB3 genes were independently associated with postprandial gastric motility. In addition, present study investigated the effects of coffee intake on gastric motility and autonomic nervous activity in young healthy subjects. Results suggest that coffee intake enhances gastric motility and autonomic nervous activity, and these effects are different between non-habitual and habitual coffee drinkers.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Effects of Coffee Intake on Gastric Motility and Autonomic Nervous Activity in Young Healthy Volunteers2012

    • Author(s)
      種村一識, 松永哲郎, 山崎英恵, 李子帆城尾恵里奈, 足達哲也, 近藤高史, 津田謹輔
    • Journal Title

      Nippon Eiyo Shokuryo Gakkaishi

      Volume: 65 Issue: 3 Pages: 113-121

    • DOI

      10.4327/jsnfs.65.113

    • NAID

      130002129281

    • ISSN
      0287-3516, 1883-2849
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 男子大学生における食後の胃運動に関連する要因の検討2012

    • Author(s)
      松永 哲郎
    • Organizer
      第59回近畿学校保健学会
    • Place of Presentation
      京都教育大学
    • Year and Date
      2012-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Gタンパク質β3サブユニットのC825T遺伝子多型と胃電気活動との関連解析2012

    • Author(s)
      松永 哲郎
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 若年日本人におけるGタンパク質β3サブユニットのC825T遺伝子多型と胃電気活動との関連解析2012

    • Author(s)
      松永 哲郎
    • Organizer
      第15回日本病態栄養学会年次学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-01-14
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Association of G-protein beta3 (GNB3) subunit C825T polymorphism with gastric myoelectrical activity in young healthy Japanese males2011

    • Author(s)
      松永 哲郎
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-14
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] グレリンおよびグレリン受容体における遺伝子多型と摂取エネルギー量、胃運動機能、自律神経活動との関連解析2011

    • Author(s)
      松永 哲郎
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル
    • Year and Date
      2011-05-19
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Gタンパク質β3サブユニットのC825T遺伝子多型と胃電気活動との関連解析

    • Author(s)
      松永哲郎
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 男子大学生における食後の胃運動に関連する要因の検討

    • Author(s)
      松永哲郎
    • Organizer
      第59回近畿学校保健学会
    • Place of Presentation
      京都教育大学
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi