Targeting cancer cells resistant to hypoxia and nutrient starvation to improve anti-cancer therapy
Project/Area Number |
23701047
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | The University of Tokyo |
Principal Investigator |
OSAWA Tsuyoshi 東京大学, 先端科学技術研究センター, 特任助教 (50567592)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 癌 / 組織・細胞 / ストレス / エピジェネティクス / ヒストン / 細胞・組織 / ヒストン修飾 |
Research Abstract |
Tumor microenvironment is critical determinant for tumor progression and metastasis. We reported that (1) hypoxia and nutrient starvation induced tumor aggressiveness, (2) and stimulated pro-cancer immunity, (3) histone demethylase JMJD1A and JHDM1D regulated tumorigenicity and tumor angiogenesis, and (4) inhibition of JMJD1A showed synergetic effect with antiangiogenesis. Thus, targeting cancer cells resistant to hypoxia and nutrient starvation can be an effective cancer treatment.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] BMP4/Thrombospondin-1 loop paracrinically inhibits tumor angiogenesis and suppresses the growth of solid tumors2014
Author(s)
Tsuchida R, Osawa T, Wang F, Nishii R, Das B, Tsuchida S, Muramatsu M, Takahashi T, Inoue T, Wada Y, Minami T, Yuasa Y, Shibuya M
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Journal Title
Oncogene
Volume: 33
Issue: 29
Pages: 3803-3811
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A major role for RCAN1 in atherosclerosis progression2013
Author(s)
Mendez-Barbero N, Esteban V, Villahoz S, Escolano A, Urso K, Alfranca A, Rodriguez C, Sanchez SA, Osawa T, Andres V, Martinez-Gonzalez J, Minami T, Redondo JM, Campanero MR
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Journal Title
EMBO Mol Med.
Volume: Dec;5(12)
Issue: 12
Pages: 1901-17
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages2013
Author(s)
Osawa T (Co-correspondence), Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, and Shibuya M
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Journal Title
Cancer Research
Volume: May 15;73(10)
Pages: 3019-3028
Related Report
Peer Reviewed
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[Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages2013
Author(s)
Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M
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Journal Title
Cancer Res
Volume: 73
Issue: 10
Pages: 3019-3028
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages2013
Author(s)
Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, and Shibuya M
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Journal Title
Cancer Research
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.2012
Author(s)
Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T,Mogushi K, Tanaka H, Osawa T, Kanki Y, et al
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Journal Title
Nature Communications
Volume: 6;3
Issue: 1
Pages: 883-883
DOI
Related Report
Peer Reviewed
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[Presentation] Down’s syndrome candidate region-1 mediates corneal opacity via corneal angiogenesis2012
Author(s)
Osawa T, Nakagawa S, Toyono T, Toyama K, Miura M, Suehiro J, Tanaka T, Usui T, Amano S, Aburatani H, Kodama T, and Minami T
Organizer
The 10th Korea-Japan Joint Symposium on Vascular Viology
Place of Presentation
徳島
Related Report
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