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Clinical impact of down-regulated plasma miR-92a levels in non-hodgkin's lymphoma

Research Project

Project/Area Number 23701088
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnosis
Research InstitutionTokyo Medical University

Principal Investigator

YOSHIZAWA Sei-ichiro  東京医科大学, 医学部, 助教 (70421063)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords非ホジキンリンパ腫 / 血清miRNA / miR-92a / 診断マーカー
Research Abstract

To evaluate the clinical relevance of the miR-92a in plasma obtained from non-Hodgkin's lymphoma patients, because miR-92 miRNA plays a crucial role in lymphogenesis, as well as tumorigenesis in lymphoid tissue. We evaluated plasma miR-92a value; MicroRNA Assays with modifications with non-Hodgkin's lymphoma and compared results with healthy subjects. Plasma miR-92a values in non-Hodgkin's lymphoma were extremely low, compared to healthy subjects. At the time of diagnosis The down-regulated plasma miR-92a increased in the complete response phase, reaching normal control levels, and again becoming down-regulated in the relapse phase. In non-Hodgkin's lymphoma patients, while a decreased level of plasma miR-92a was evident, indicating that the discrepancy lymph circulating miR-92a might be an important clinical issue. The plasma miR-92a value could be a novel biomarker for monitoring lymphoma patients, especially in those with indolent lymphoma.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (13 results) Book (1 results)

  • [Journal Article] Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders2012

    • Author(s)
      Yoshizawa S, Ohyashiki JH, Ohyashiki M, Umezu T, Suzuki K, Inagaki A, Ohyashiki K
    • Journal Title

      Blood Cancer J.

      Volume: 2(1)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders.2012

    • Author(s)
      Yoshizawa S, Ohyashiki JH, Ohyashiki M, Umezu T, Suzuki K, Inagaki A, Iida S, Ohyashiki K.
    • Journal Title

      Blood Cancer J.

      Volume: 2(1) Issue: 1 Pages: e53-e53

    • DOI

      10.1038/bcj.2011.51

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of down-regulated plasma miR-92a levels in non-Hodgkin's lymphoma2011

    • Author(s)
      Ohyashiki K, Umezu T, Yoshizawa S, Ito Y, Ohyashiki M, Kawashima H, Tanaka M, Kuroda M, Ohyashiki JH
    • Journal Title

      PLoS One

      Volume: 6(2)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical impact of down-regulated plasma miR-92a levels in non-Hodgkin's lymphoma.2011

    • Author(s)
      Ohyashiki K, Umezu T, Yoshizawa S, Ito Y, Ohyashiki M, Kawashima H, Tanaka M, Kuroda M, Ohyashiki JH
    • Journal Title

      PLoS One.

      Volume: 6(2)

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Lower plasma miR-92a levels predict shorter progression-free survival in newly diagnosed symptomatic multiple myeloma patients2013

    • Author(s)
      Yoshizawa S
    • Organizer
      55th Annual meeting of ASH
    • Place of Presentation
      New Orieans
    • Year and Date
      2013-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Feasibility of plasma miR-92a as a prognostic marker in newly diagnosed multiple myeloma patients2013

    • Author(s)
      Yoshizawa S
    • Organizer
      日本血液学会
    • Place of Presentation
      札幌
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Lower plasma miR-92a levels in newly diagnosed symptomatic multiple myeloma patients with poor-risk cytogenetics2013

    • Author(s)
      Yoshizawa S
    • Organizer
      14th International Myeloma Workshop
    • Place of Presentation
      京都
    • Year and Date
      2013-04-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Feasibility of plasma MiR-92a as a prognostic marker in newly diagnosed multiple myeloma patients.2013

    • Author(s)
      Yoshizawa S
    • Organizer
      日本血液学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lower Plasma miR-92a Levels in Newly Diagnosed Symptomatic Multiple Myeloma patients with Poor-Risk Cytogenetics.2013

    • Author(s)
      Yoshizawa S
    • Organizer
      14th International Myeloma Workshop
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Lower plasma miR-92a levels predict shorter progression-free survival in newly diagnosed symptomatic multiple myeloma patients.2013

    • Author(s)
      Yoshizawa S
    • Organizer
      55th Annual Meeting of ASH
    • Place of Presentation
      New Orleans
    • Related Report
      2013 Annual Research Report
  • [Presentation] Plasma miR=92a levels in multiple myeloma correlate with T cell derived miR-92a and restored in bortezomib responder2011

    • Author(s)
      Yoshizawa S, Ohyashiki JH, Ohyashiki M, Umezu T, Suzuki K, Inagaki A, Iida S, Ohyashiki K
    • Organizer
      53rd ASH annual meeting and exposition
    • Place of Presentation
      San Diego
    • Year and Date
      2011-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 多発性骨髄腫における血清miR-92a低下は末梢T細胞由来miR-92aを反映する2011

    • Author(s)
      吉澤成一郎、大屋敷一馬、大屋敷倫代、藤本博昭、後藤守孝、後藤明彦、北原俊彦、岩渕多光子、梅津知宏、小林千晶、廣田綾子、大屋敷純子
    • Organizer
      第36回日本骨髄腫研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-12
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 形質細胞腫瘍とマイクロRNA2011

    • Author(s)
      吉澤成一郎、梅津知宏、藤本博昭、後藤守孝、木村之彦、大屋敷一馬、大屋敷純子、飯田真介、鈴木憲史
    • Organizer
      第11回血液疾患フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-10-22
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 多発性骨髄腫における血清miR-92aの臨床的意義2011

    • Author(s)
      吉澤成一郎、梅津知宏、藤本博昭、後藤守孝、木村之彦、大屋敷一馬、大屋敷純子
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-16
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Clinical impact of low plasma miR-92a levels in monoclonal gammopathies2011

    • Author(s)
      Yoshizawa S, Ohyashiki JH, Umezu T, Suzuki K, Inagaki A, Iida S, Ohyashiki K
    • Organizer
      The 13th International Myeloma Workshop
    • Place of Presentation
      Paris
    • Year and Date
      2011-05-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Clinical Impact Of Low Plasma miR-92a Levels in Monoclonal ganmmopathies2011

    • Author(s)
      Sei-ichiro Yoshizawa, Junko H. Ohyashiki, Tomohiro Umezu, Kenshi Suzuki, Atsushi Inagaki, Shinsuke Iida, and Kazuma Ohyashiki
    • Organizer
      The 13th International Myeloma Workshop
    • Place of Presentation
      Paris
    • Related Report
      2011 Research-status Report
  • [Presentation] Plasma Mir-92a Levels in Multiple Myeloma Correlate with T-cell-Derived Mir-92a and Restored in Bortezomib Responder2011

    • Author(s)
      Sei-ichiro Yoshizawa, Junko H. Ohyashiki, Michiyo Ohyashiki, Tomohiro Umezu, Kenshi Suzuki, Atsushi Inagaki, Shinsuke Iida, and Kazuma Ohyashiki
    • Organizer
      53rd ASH annual meeting and Exposition
    • Place of Presentation
      San Diego、CA
    • Related Report
      2011 Research-status Report
  • [Book] 血液領域におけるmiRNA:Trends in Hematologcal Malignancies2013

    • Author(s)
      吉澤成一郎、大屋敷一馬
    • Publisher
      メディカルレビュー社
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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