| Project/Area Number |
23701091
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KANAYAMA Yousuke 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (60435641)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 89Zr / 小型サイクロトロン / RI 製造 / PET イメージング / 抗体 / 65Zn / RI製造 / PET / 抗体イメージング / 抗体PETイメージング |
|---|
| Research Abstract |
For development of biomacromolecular PET probes which require long-term tracking, a production method for long-lived positron-emitting metal radionuclides was investigated using small cyclotron. We established a convenient method for yttrium-foil irradiation with a gold disc support and succeeded the production of ^<89>Zr, which has a half-life of 78.4 hours. In a PET imaging of tumor-bearing mouse with the ^<89>Zr-labeled antibody, high accumulation was observed in tumor regions even 8 days after injection. This metal-foil target irradiation method has a potential for various radioisotope productions.
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