Production of long-lived radioisotopes using small cyclotron for labeling of biomacromolecules

Research Project

Project/Area Number	23701091
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor diagnosis
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	KANAYAMA Yousuke 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (60435641)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	89Zr / 小型サイクロトロン / RI 製造 / PET イメージング / 抗体 / 65Zn / RI製造 / PET / 抗体イメージング / 抗体PETイメージング
Research Abstract	For development of biomacromolecular PET probes which require long-term tracking, a production method for long-lived positron-emitting metal radionuclides was investigated using small cyclotron. We established a convenient method for yttrium-foil irradiation with a gold disc support and succeeded the production of ^<89>Zr, which has a half-life of 78.4 hours. In a PET imaging of tumor-bearing mouse with the ^<89>Zr-labeled antibody, high accumulation was observed in tumor regions even 8 days after injection. This metal-foil target irradiation method has a potential for various radioisotope productions.