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Identification of cells of origin in lymphomas and the target of γ-radiation

Research Project

Project/Area Number 23710067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNigata University of Phermacy and Applied Life Sciences (2012)
Niigata University (2011)

Principal Investigator

GO Rieka  新潟薬科大学, 薬学部, 研究員 (40584769)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords放射線発がん / 発がん母体細胞 / Bcl11b 遺伝子 / Bcl11b遺伝子
Research Abstract

Cell of origin in γ-radiation induced mouse thymic lymphomas remains obscure. In this study, we generated mouse models in which loss of one Bcl11b allele occurs in thymocytes at different developmental stages and examined expansion and differentiation of premalignant thymocytes after irradiation. We showed that thymocytes at the immature stage were cells of origin and premalignant thymocytes retained the capacity to proliferate and differentiate. Also, loss of Bcl11b allele in thymocytes led to impaired cell cycle arrest at S phase after irradiation, suggesting that the impairment contributes to the development of the premalignant thymocytes.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele.2013

    • Author(s)
      Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R.
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 8 Pages: 1009-1016

    • DOI

      10.1111/cas.12193

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis2012

    • Author(s)
      R. Go, K. Takizawa, S. Hirose, Y. Katsuragi,Y. Aoyagi, S, Y. Mishima and R. Kominami
    • Journal Title

      Leukemia Research

      Volume: 36 Issue: 8 Pages: 1035-1040

    • DOI

      10.1016/j.leukres.2012.04.028

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 放射線誘発胸腺リンパ腫発症における放射線照射の標的細胞、発がん母体細胞の同定2012

    • Author(s)
      郷梨江香
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2012-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 分化胸腺細胞が放射線誘発胸腺リンパ腫の発がん母体細胞、放射線照射の標的細胞と成り得る2011

    • Author(s)
      郷梨江香
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(兵庫県)
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Cellsinthethymusofthe gamma-radiationtargetandoforiginin lymphomainBcl11bheterozygous mice2011

    • Author(s)
      郷梨江香
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Cells in the thymus of the gamma-radiation target and of origin in lymphoma in Bcl11b heterozygous mice2011

    • Author(s)
      Rieka Go
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      The Palace of Culture and Science(ポーランド)
    • Year and Date
      2011-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Cells in the thymus of the gamma-radiation target and of origin in lymphoma in Bcl11b heterozygous mice.2011

    • Author(s)
      郷 梨江香
    • Organizer
      14th International Congress of Radiation Research
    • Place of Presentation
      The Palace of Culture and Science(ワルシャワ)
    • Related Report
      2011 Research-status Report
  • [Presentation] Cells in the thymus of the gamma-radiation target and of origin in lymphoma in Bcl11b heterozygous mice2011

    • Author(s)
      郷 梨江香
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 分化胸腺細胞が放射線誘発胸腺リンパ腫の発がん母体細胞、放射線照射の標的細胞と成り得る2011

    • Author(s)
      郷 梨江香
    • Organizer
      第54回日本放射線影響学会
    • Place of Presentation
      神戸商工会議所会館(神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 放射線誘発胸腺リンパ腫発症における放射線照射の標的細胞、発がん母体細胞の同定

    • Author(s)
      郷 梨江香
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Book] seriesモデル動物利用マニュアル疾患モデルの作製と利用-がん2012

    • Author(s)
      中村卓郎(編集委員)
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2012 Final Research Report
  • [Book] series モデル動物利用マニュアル 疾患モデルの作製と応用 がん2012

    • Author(s)
      木南 凌/郷 梨江香
    • Publisher
      株式会社エル・アイ・シー
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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