| Project/Area Number |
23710082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
KOMOIKE Yuta 東京女子医科大学, 医学部, 准講師 (70386556)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 環境毒性学 / 小胞体ストレス応答 / ゼブラフィッシュ / トリブチルスズ / トキシコロジー / 小胞体ストレス |
|---|
| Research Abstract |
For the purpose of understanding the adverse effects of toxic chemical compounds on organisms and their underlying mechanisms from the environmental toxicological perspectives, we especially focus on the roles of the endoplasmic reticulum (ER). This study was conducted to solve the mechanisms and toxicological meanings of the ER stress response evoked by the exposure to environmental pollutants at an individual revel. Exposure of the cells to tributyltin, known as an important marine pollutant, or the ER stress inducers activated the ER stress response transduction pathways. In the study using zebrafish as a model organism, various ER stress responses, differently evoked by the different types of substances, were observed in an organ-specific manner. It was also suggested that the involvement of the ER stress response in the neurotoxicity of TBT.
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