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Expansion of the study of the endoplasmic reticulum stress using zebrafish into environmental toxicology

Research Project

Project/Area Number 23710082
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTokyo Women's Medical University

Principal Investigator

KOMOIKE Yuta  東京女子医科大学, 医学部, 准講師 (70386556)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords環境毒性学 / 小胞体ストレス応答 / ゼブラフィッシュ / トリブチルスズ / トキシコロジー / 小胞体ストレス
Research Abstract

For the purpose of understanding the adverse effects of toxic chemical compounds on organisms and their underlying mechanisms from the environmental toxicological perspectives, we especially focus on the roles of the endoplasmic reticulum (ER). This study was conducted to solve the mechanisms and toxicological meanings of the ER stress response evoked by the exposure to environmental pollutants at an individual revel. Exposure of the cells to tributyltin, known as an important marine pollutant, or the ER stress inducers activated the ER stress response transduction pathways. In the study using zebrafish as a model organism, various ER stress responses, differently evoked by the different types of substances, were observed in an organ-specific manner. It was also suggested that the involvement of the ER stress response in the neurotoxicity of TBT.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (17 results) (of which Invited: 2 results) Remarks (4 results)

  • [Journal Article] Novel compound heterozygous mutations of POLR3A revealed by whole-exome sequencing in a patient with hypomyelination2014

    • Author(s)
      Shimojima, K., Shimada, S., Tamasaki, A., Akaboshi, S., Komoike, Y., Saito, A., Furukawa, T., Yamamoto, T.
    • Journal Title

      Brain Dev.

      Volume: 36 Issue: 4 Pages: 315-321

    • DOI

      10.1016/j.braindev.2013.04.011

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish2013

    • Author(s)
      Yuta Komoike, Masato Matsuoka
    • Journal Title

      Aquatic Toxicology

      Volume: 142-143 Pages: 221-229

    • DOI

      10.1016/j.aquatox.2013.08.017

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential teratogenicity of methimazole: Exposure of zebrafish embryos to methimazole causes similar developmental anomalies to human methimazole embryopathy2013

    • Author(s)
      Yuta Komoike, Masato Matsuoka, and Kenjiro Kosaki
    • Journal Title

      Birth Defects Research (Part B)

      Volume: 98 Issue: 3 Pages: 222-229

    • DOI

      10.1002/bdrb.21057

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus-Merzbacher disease patient with a partial PLP1 duplication2012

    • Author(s)
      Keiko Shimojima
    • Journal Title

      Journal of Human Genetics

      Volume: 57 Issue: 9 Pages: 580-586

    • DOI

      10.1038/jhg.2012.71

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a novel KRAS mutation identified in Noonan Syndrome2012

    • Author(s)
      Razzaque, Md.A., Komoike, Y., Nishizawa T., Inai, K., Furutani, M., Higashinakagawa, T., Matsuoka, R.
    • Journal Title

      Am. J. Med. Genet. A

      Volume: 158A Issue: 3 Pages: 524-532

    • DOI

      10.1002/ajmg.a.34419

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of salubrinal on cadmium-induced apoptosis in HK-2 human renal proximal tubular cells2012

    • Author(s)
      Komoike, Y., Inamura, H., Matsuoka, M.
    • Journal Title

      Arch. Toxicol

      Volume: 86 Issue: 1 Pages: 37-44

    • DOI

      10.1007/s00204-011-0742-x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] メチマゾールの催奇性の検討 : メチマゾール性胎児障害とゼブラフィッシュモデルの類似性2013

    • Author(s)
      蔣池勇太,松岡雅人,小崎健次郎
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] ゼブラフィッシュモデルの毒性学研究への展開2013

    • Author(s)
      蔣池勇太
    • Organizer
      第31回関西生殖発生毒性フォーラム
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] トリブチルスズ曝露ゼブラフィッシュにおける小胞体ストレス応答の解析2013

    • Author(s)
      蔣池勇太,松岡雅人
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] ゼブラフィッシュを用いた小胞体ストレス応答解析モデルの確立2013

    • Author(s)
      蔣池勇太
    • Organizer
      第347回東京女子医科大学学会例会, 平成23年度山川寿子研究奨励賞受賞者発表
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ゼブラフィッシュを用いた小胞体ストレス応答の検討2012

    • Author(s)
      蔣池勇太,松岡雅人
    • Organizer
      第24回日本産業衛生学会産業神経・行動学研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] トリブチルスズが惹起する小胞体ストレス応答のゼブラフィッシュを用いた解析2012

    • Author(s)
      蔣池勇太,松岡雅人
    • Organizer
      第7回臨床ストレス応答学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Cadmium induces ER stress and apoptosis in renal proximal tubular cells : protection by salubrinal2012

    • Author(s)
      Komoike, Y., Matsuoka, M.
    • Organizer
      The 6th International congress of Asia society of toxicology
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] ゼブラフィッシュを用いたメチマゾールの催奇性の検討2012

    • Author(s)
      蔣池勇太,松岡雅人,小崎健次郎
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ゼブラフィッシュを用いたトリブチルスズの惹起する小胞体ストレス応答の解析2012

    • Author(s)
      蔣池勇太、松岡雅人
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] メチマゾール曝露によるゼブラフィッシュの発生異常2011

    • Author(s)
      蔣池勇太、小崎健次郎
    • Organizer
      第51回日本先天異常学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] メチマゾールの催奇性の検討:メチマゾール性胎児障害とゼブラフィッシュモデルの類似性

    • Author(s)
      蒋池勇太, 松岡雅人, 小崎健次郎
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] トリブチルスズ曝露ゼブラフィッシュにおける小胞体ストレス応答の解析

    • Author(s)
      蒋池勇太, 松岡雅人
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] ゼブラフィッシュを用いた小胞体ストレス応答解析モデルの確立

    • Author(s)
      蒋池勇太
    • Organizer
      第347回東京女子医科大学学会例会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ゼブラフィッシュを用いた小胞体ストレス応答の検討

    • Author(s)
      蒋池勇太, 松岡雅人
    • Organizer
      第24回日本産業衛生学会 産業神経・行動学研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] タイトル トリブチルスズが惹起する小胞体ストレス応答のゼブラフィッシュを用いた解析

    • Author(s)
      蒋池勇太, 松岡雅人
    • Organizer
      第7回臨床ストレス応答学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Cadmium induces ER stress and apoptosis in renal proximal tubular cells: protection by salubrinal

    • Author(s)
      Yuta Komoike, Masato Matsuoka
    • Organizer
      The 6th International congress of Asia society of toxicology
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] ゼブラフィッシュを用いたメチマゾールの催奇性の検討

    • Author(s)
      蒋池勇太、松岡正人、小崎健次郎
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Remarks] 東京女子医科大学研究業績データベース:教員情報(蔣池)

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kyoinId=ymdigbgoggk&keytype=3&keyword=komoike+

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京女子医科大学衛生学公衆衛生学(一)

    • URL

      http://www.twmu.ac.jp/Basic/hygiene1/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京女子医科大学 研究業績データベース

    • URL

      http://gyoseki.twmu.ac.jp/twmhp/KgApp?kozac=C11100000000&year=2013

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京女子医科大学 衛生学公衆衛生学(一)

    • URL

      http://www.twmu.ac.jp/Basic/hygiene1/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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