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Application of biogenic stealthy gold/magnetic composite nanoparticle to MRI contrast agent

Research Project

Project/Area Number 23710133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nanomaterials/Nanobioscience
Research InstitutionOsaka Prefecture University

Principal Investigator

KINOSHITA Takuya  大阪府立大学, 工学(系)研究科(研究院), 助教 (90453141)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords磁性ナノ粒子 / MRI造影剤 / PEG / 噴霧熱分解法 / ハイパーサーミア / MRI造影剤 / PEG / 金 / 液相PLD法
Research Abstract

Magnetic composite nanoparticles with in vivo dispersibility, stealthy and capacity to bind a targeting biomolecule have been synthesized. Magnetic iron oxide nanoparticles synthesized by co-precipitation method were utilized as a core of composite particle. Polyethylene glycol or gold was bound on the surface of iron oxide. Magnetic La-Sr-Mn oxide fine particles were synthesized for cancer treatment. These particles generated heat in the AC magnetic field, and particle temperature increased quickly with time, attaining constant values.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (41 results)

All 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (34 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Synthesis of La0.75Sr0.25MnO3 fine particles for magnetic hyperthermia by ultrasonic spray pyrolysis2014

    • Author(s)
      Takuya Kinoshita, Takamitsu Furuyabu, Motoaki Adachi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of gold/iron-oxide composite nanoparticles by ultrasonic spray pyrolysis for magnetic separation of biomolecules2012

    • Author(s)
      Shuji Watanabe, Takuya Kinoshita, Motoaki Adachi
    • Journal Title

      Proceeding of 19th Regional Symposium on Chemical Engineering

      Volume: D50-1-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of perovskite manganite magnetic fine particles by ultrasonic spray pyrolysis for self-controlled magnetic hyperthermia2012

    • Author(s)
      Takamitsu Furuyabu, Ayako Yasuda, Takuya Kinoshita, Motoaki Adachi
    • Journal Title

      Proceeding of 19th Regional Symposium on Chemical Engineering

      Volume: A55-1-4

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of cobalt nanoparticle and fabrication of magnetoresistance devices by ion-assisted aerosol generation method2011

    • Author(s)
      Hiroyuki Shirai, Takuya Kinoshita, Motoaki Adachi
    • Journal Title

      Aerosol Science and Technology

      Volume: 45 Issue: 10 Pages: 1240-1244

    • DOI

      10.1080/02786826.2011.588729

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of La0.75Sr0.25MnO3 fine particles for self-controlled magnetic heating hyperthermia by ultrasonic spray pyrolysis

    • Author(s)
      Takuya Kinoshita, Takamitsu Furuyabu, and Motoaki Adachi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: (In press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 噴霧熱分解法による磁性微粒子の合成とがん温熱療法への応用2013

    • Author(s)
      木下卓也,古薮孝充,足立元明
    • Organizer
      化学工学会第45回秋季大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体内利用に向けたPEG/酸化鉄ナノ粒子の合成2013

    • Author(s)
      矢部奈生子,木下卓也,足立元明
    • Organizer
      第30回エアロゾル科学・技術研究討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 噴霧熱分解法による磁気ハイパーサーミア粒子の粒径制御2013

    • Author(s)
      貴志暢大,木下卓也,足立元明
    • Organizer
      第30回エアロゾル科学・技術研究討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 噴霧熱分解法による磁性微粒子の合成とがん温熱療法への応用2013

    • Author(s)
      木下卓也、古薮孝充、足立元明
    • Organizer
      化学工学会 第45回秋季大会
    • Place of Presentation
      岡山大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 噴霧熱分解法による磁気ハイパーサーミア粒子の粒径制御2013

    • Author(s)
      貴志暢大、古薮孝充、木下卓也、足立元明
    • Organizer
      第30回エアロゾル科学・技術研究討論会
    • Place of Presentation
      京都大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体内利用に向けたPEG/酸化鉄ナノ粒子の合成2013

    • Author(s)
      矢部奈生子、木下卓也、足立元明
    • Organizer
      第30回エアロゾル科学・技術研究討論会
    • Place of Presentation
      京都大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 温度自己制御型ハイパーサーミア用微粒子の開発2012

    • Author(s)
      木下卓也,古薮孝充,保田亜矢子,足立元明
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      東京
    • Year and Date
      2012-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of perovskite manganite magnetic fine particles by ultrasonic spray pyrolysis for self-controlled magnetic hyperthermia2012

    • Author(s)
      T. Furuyabu, A. Yasuda, T. Kinoshita, M. Adachi
    • Organizer
      19th Regional Symposium on Chemical Engineering (RSCE 2012)
    • Place of Presentation
      バリ,インドネシア
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of gold/iron-oxide composite nanoparticles by ultrasonic spray pyrolysis for magnetic separation of biomolecules2012

    • Author(s)
      S. Watanabe, T. Kinoshita, M. Adachi
    • Organizer
      19th Regional Symposium on Chemical Engineering (RSCE 2012)
    • Place of Presentation
      バリ,インドネシア
    • Related Report
      2013 Final Research Report
  • [Presentation] 磁気ハイパーサーミアに向けた温度自己制御型磁性微粒子の開発2012

    • Author(s)
      古薮孝充,保田亜矢子,木下卓也,足立元明
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 噴霧熱分解合成磁性粒子が開く新しい癌温熱療法2012

    • Author(s)
      古薮孝充,保田亜矢子,木下卓也,足立元明
    • Organizer
      第29回エアロゾル科学・技術研究討論会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] 温度自己制御型ハイパーサーミア用微粒子の合成2012

    • Author(s)
      古薮孝充,保田亜矢子,木下卓也,足立元明
    • Organizer
      第29回エアロゾル科学・技術研究討論会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of La0.75Sr0.25MnO3 Fine Particles for Magnetic Hyperthermia by Ultrasonic Spray Pyrolysis2012

    • Author(s)
      T. Kinoshita, T. Furuyabu, A. Yasuda, M. Adachi
    • Organizer
      9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
    • Place of Presentation
      ミネアポリス,アメリカ
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of La0.75Sr0.25MnO3 Fine Particles for Magnetic Hyperthermia by Ultrasonic Spray Pyrolysis2012

    • Author(s)
      Takuya Kinoshita, Takamitsu Furuyabu, Ayako Yasuda, Motoaki Adachi
    • Organizer
      9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
    • Place of Presentation
      ミネアポリス、アメリカ
    • Related Report
      2012 Research-status Report
  • [Presentation] Synthesis of magnetic fine particles by ultrasonic spray pyrolysis for self-controlled magnetic hyperthermia2012

    • Author(s)
      Takamitsu Furuyabu, Ayako Yasuda, Takuya Kinoshita, Motoaki Adachi
    • Organizer
      19thRegional Symposium on Chemical Engineering
    • Place of Presentation
      バリ、インドネシア
    • Related Report
      2012 Research-status Report
  • [Presentation] Synthesis of gold/iron-oxide composite nanoparticles by ultrasonic spray pyrolysis for magnetic separation of biomolecules2012

    • Author(s)
      Shuji Watanabe, Toshiyuki Tani, Takuya Kinoshita, Motoaki Adachi
    • Organizer
      19thRegional Symposium on Chemical Engineering
    • Place of Presentation
      バリ、インドネシア
    • Related Report
      2012 Research-status Report
  • [Presentation] 磁気ハイパーサーミアに向けた温度自己制御型磁性微粒子の開発2012

    • Author(s)
      古薮 孝充, 保田 亜矢子, 木下 卓也, 足立 元明
    • Organizer
      化学工学会第44回秋季大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] 温度自己制御型ハイパーサーミア用微粒子の開発2012

    • Author(s)
      木下卓也、古薮孝充、保田亜矢子、足立元明
    • Organizer
      化学工学会第77回年会
    • Place of Presentation
      工学院大学
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthesis of gold/iron-oxide composite nanoparticles by liquid laser ablation for biomedical applications2011

    • Author(s)
      M. Nama, T. Kinoshita, M. Adcahi
    • Organizer
      6th Asia Pacific Chemical Reaction Engineering Symposium(APCRE2011)
    • Place of Presentation
      北京,中国
    • Year and Date
      2011-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of gold/iron-oxide composite nanoparticles and adsorption of bovine serum albumin on particle surface2011

    • Author(s)
      T. Tani, S. Watanabe, T. Kinoshita, M. Adachi
    • Organizer
      6th Asia Pacific Chemical Reaction Engineering Symposium (APCRE2011)
    • Place of Presentation
      北京,中国
    • Year and Date
      2011-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 金/酸化鉄磁性複合ナノ粒子へのBSAたんぱく質の吸着量の評価2011

    • Author(s)
      谷俊之,渡邊周二,木下卓也,足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] バイオ分野での応用に向けた金酸化鉄複合ナノ粒子の合成2011

    • Author(s)
      渡邊周二,谷俊之,木下卓也,足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 液相レーザーアブレーションによる金/酸化鉄磁性複合ナノ粒子の合成2011

    • Author(s)
      名間瑞樹,木下卓也,足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波噴霧熱分解法によって合成したLaSrMn系酸化物微粒子の交流磁場中での発熱特性の評価2011

    • Author(s)
      古薮孝充,木下卓也,足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波噴霧熱分解法による磁気ハイパーサーミア用LaSrMn系酸化物微粒子の合成2011

    • Author(s)
      古薮孝充,木下卓也,足立元明
    • Organizer
      第28回エアロゾル科学・技術研究討論会
    • Place of Presentation
      堺
    • Year and Date
      2011-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波噴霧熱分解法による金酸化鉄複合ナノ粒子の合成2011

    • Author(s)
      渡邊周二,谷俊之,木下卓也,足立元明
    • Organizer
      第28回エアロゾル科学・技術研究討論会
    • Place of Presentation
      堺
    • Year and Date
      2011-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 超音波噴霧熱分解法による金酸化鉄複合ナノ粒子の合成2011

    • Author(s)
      渡邊周二、谷俊之、木下卓也、足立元明
    • Organizer
      第28回エアロゾル科学・技術研究討論会
    • Place of Presentation
      大阪府立大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 超音波噴霧熱分解法による磁気ハイパーサーミア用LaSrMn系酸化物微粒子の合成2011

    • Author(s)
      古薮孝充、木下卓也、足立元明
    • Organizer
      第28回エアロゾル科学・技術研究討論会
    • Place of Presentation
      大阪府立大学
    • Related Report
      2011 Research-status Report
  • [Presentation] バイオ分野での応用に向けた金酸化鉄複合ナノ粒子の合成2011

    • Author(s)
      渡邊周二、谷俊之、木下卓也、足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 金/酸化鉄磁性複合ナノ粒子へのBSAたんぱく質の吸着量の評価2011

    • Author(s)
      谷俊之、渡邊周二、木下卓也、足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 液相レーザーアブレーションによる金/酸化鉄磁性複合ナノ粒子の合成2011

    • Author(s)
      名間瑞樹、木下卓也、足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 超音波噴霧熱分解法によって合成したLaSrMn系酸化物微粒子の交流磁場中での発熱特性の評価2011

    • Author(s)
      古薮孝充、木下卓也、足立元明
    • Organizer
      化学工学会第43回秋季大会
    • Place of Presentation
      名古屋工業大学
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthesis of gold/iron-oxide composite nanoparticles and adsorption of2011

    • Author(s)
      T.Tani, S.Watanabe, T.Kinoshita, M.Adachi
    • Organizer
      6th Asia Pacific Chemical Reaction Engineering
    • Place of Presentation
      北京、中国
    • Related Report
      2011 Research-status Report
  • [Presentation] Synthesis of gold/iron-oxide composite nanoparticles by liquid laser2011

    • Author(s)
      M.Nama, T.Kinoshita, M.Adcahi
    • Organizer
      6th Asia Pacific Chemical Reaction Engineering
    • Place of Presentation
      北京、中国
    • Related Report
      2011 Research-status Report
  • [Book] Generation of Nanoparticles and Its Applications, Nanodroplets2013

    • Author(s)
      M. Adachi and T. Kinoshita
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.chemeng.osakafu-u.ac.jp/group7/indexJ.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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