Multiple approach to the exploration of neural substrates for interval timing in rats

• Project/Area Number: 23730712
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental psychology
• Research Institution: Doshisha University
• Principal Investigator: TOSHIMICHI Hata 同志社大学, 心理学部, 教授 (50399044)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 時間評価 / インターバルタイミング / 背側線条体 / SBFモデル / Striatal beat frequency / NMDA / グルタミン酸受容体 / アセチルコリン受容体 / 情動

Outline of Final Research Achievements

We explored the role of the dorsal striatum in interval timing ranging from seconds to minutes. Intra dorsal striatum injection of an NMDA receptor antagonist impaired the acquisition of the memory for temporal duration. Moreover, c-Fos protein expression was enhanced during temporal memory formation in the dorsal striatum. Taken together, these findings suggest that the dorsal striatum plays an important role in the formation of memory for temporal duration.

Research Products

• [Journal Article] Post-acquisition hippocampal NMDA receptor blockade sustains retention of spatial reference memory in Morris water maze (2014)
  • Author(s): Shinohara, K., Hata, T.
  • Journal Title: Behavioural Brain Research Volume: 259 Pages: 261-267
  • DOI: 10.1016/j.bbr.2013.11.016
  • Peer Reviewed
• [Journal Article] Morris型水迷路課題獲得後のNMDA受容体阻害は空間記憶保持を向上する (2014)
  • Author(s): 篠原恵介・畑 敏道
  • Journal Title: 心理学研究 Volume: 84 Pages: 618-624
  • Peer Reviewed
• [Journal Article] Glutamate - a forgotten target for interval timing (2011)
  • Author(s): Toshimichi Hata
  • Journal Title: Frontiers in Integrative Neuroscience Volume: 5 Pages: 27-27
  • DOI: 10.3389/fnint.2011.00027
  • Peer Reviewed
• [Journal Article] Intra-ventral tegmental area or intracerebroventricular orexin-A increases the intra-cranial self-stimulation threshold via activation of the corticotropin-releasing factor system in rats (2011)
  • Author(s): Hata T, et al
  • Journal Title: Eur J Neurosci Volume: 34 Issue: 5 Pages: 816-826
  • DOI: 10.1111/j.1460-9568.2011.07808.x
  • Peer Reviewed
• [Presentation] Effect of an intra-dorsal striatum injection of a muscarinic acetylcholine m1 receptors blocker, pirenzepin, on memorization of duration in rats (2014)
  • Author(s): Toshimichi Hata
  • Organizer: Society for Neuroscience 44th annual meeting
  • Place of Presentation: Washigton D.C., USA
  • Year and Date: 2014-11-19
• [Presentation] The activity of c-Fos and EGR-1 in the dorsal striatum increases during memorization of duration (2014)
  • Author(s): Toshimichi Hata
  • Organizer: The 74th Annual Meeting of the Japanese Society for Animal Psychology
  • Place of Presentation: Inuyama, Japan
  • Year and Date: 2014-07-20
• [Presentation] Is interval ltiming modified by conditioned fear in rats?: An investigation using a self-start short/long discrimination task (2014)
  • Author(s): Taisuke Kamada, Toshimichi Hata
  • Organizer: The 74th Annual Meeting of the Japanese Society for Animal Psychology
  • Place of Presentation: Inuyama, Japan
  • Year and Date: 2014-07-19
• [Presentation] 条件性恐怖はラットにおいて時間の過小評価と時間弁別精度の低下を引き起こす (2013)
  • Author(s): 鎌田泰輔・畑 敏道
  • Organizer: 日本動物心理学会第73回大会
  • Place of Presentation: 筑波大学
• [Presentation] The effect of conditioned fear on interval timing in rats (2013)
  • Author(s): Kamada, T., Hata, T.
  • Organizer: Society for Neuroscience 43th annual meeting
  • Place of Presentation: San Diego
• [Presentation] Effect of NMDA receptor blockade on acquisition of memory for duration in rats. (2012)
  • Author(s): Oka, M., Ishino, S., Yanai, S., Okaichi, H., Hata, T.
  • Organizer: 42th Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] 心は脳にある。時間評価の行動科学と行動神経科学 (2012)
  • Author(s): 畑 敏道
  • Organizer: 日本心理学会公開シンポジウム 基礎心理学の展開シリーズ 心理学における動物実験の実際
  • Place of Presentation: 神戸医療大学
• [Presentation] Hippocampal acetylcholine efflux is enhanced during negative patterning discrimination task compared with elemental discrimination task in rats (2012)
  • Author(s): Toshimichi Hata
  • Organizer: ICSP 16th Biennial meeting
  • Place of Presentation: Jaen, Spain
  • Invited
• [Presentation] Post-training N-methyl-D-aspartate receptor blockade facilitates spatial memory retention in rats performing the Morris water maze task (2012)
  • Author(s): Shinohara, K., Uekita, T., Hata, T.
  • Organizer: 42th Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] 水迷路課題獲得後の AP5 脳室内慢性投与はラットの空間記憶の忘却を抑制する (2012)
  • Author(s): 篠原恵介・畑 敏道
  • Organizer: 日本動物心理学会第72回大会
  • Place of Presentation: 関西学院大学
• [Presentation] 背内側線条体内ＮＭＤＡ受容体拮抗薬ＡＰ‐５の投与がラットの時程の学習に及ぼす影響 (2011)
  • Author(s): 岡 真理子・畑 敏道
  • Organizer: 第71回日本動物心理学会
  • Place of Presentation: 慶応大学（東京）
• [Presentation] ラットにおける自発的走行が空間記憶の獲得に与える効果 (2011)
  • Author(s): 松尾知香・畑 敏道
  • Organizer: 第71回日本動物心理学会
  • Place of Presentation: 慶応大学（東京）
• [Presentation] 保持期間中のNMDA受容体阻害剤AP5脳室内慢性投与が忘却に与える影響の検討 (2011)
  • Author(s): 篠原恵介・畑 敏道
  • Organizer: 第71回日本動物心理学会
  • Place of Presentation: 慶応大学（東京）
• [Presentation] ラットの時程の記憶の獲得に与えるNMDA型グルタミン酸受容体阻害薬MK-801投与の効果 (2011)
  • Author(s): 畑 敏道・石野誠也・柳井修一・岡市広成
  • Organizer: 第71回日本動物心理学会
  • Place of Presentation: 慶応大学（東京）
• [Book] 動物たちは何を考えている? －動物心理学の挑戦－ (2015)
  • Author(s): 畑 敏道
  • Total Pages: 304
  • Publisher: 技術評論社