Development of near-IR responsive triple-targeting anti-cancer drug using efficient silyl-photosensitizer

• Project/Area Number: 23750145
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional materials chemistry
• Research Institution: Gunma University
• Principal Investigator: HORIUCHI Hiroaki 群馬大学, 大学院・工学研究科, 助教 (00334136)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: がん / 光 / 治療 / 一重項酸素 / 近赤外光 / 光機能物質 / 光線力学療法 / 光増感剤 / ドラッグデリバリー

Research Abstract

To develop the near-IR responsive anticancer drug, we have developed the near-IR responsive drug delivery system, which consists with nanosized drug carrier, olefin unit, and photosensitizer, and efficient near-IR responsive photosensitizer.
We have estimated the dissociation efficiency of olefin unit by singlet oxygen and have discussed the possibility to release the photosensitizer from the nanosized carrier. We have also improve the photosensitizer by tuning light absorption efficiency.

Research Products

• [Journal Article] Silylation Enhancement of Photodynamic Activity of Tetraphenylporphyrin Derivative.J.Photochem.Photobiol. (2011)
  • Author(s): Horiuchi, H., Kameya, T., Hosaka, M., Yoshimura, K., Kyushin, S., Matsumoto, H., Okutsu, T., Takeuchi, T., Hiratsuka, H.
  • Journal Title: J.Photochem.Photobiol. Volume: 221 Issue: 1 Pages: 98-104
  • DOI: 10.1016/j.jphotochem.2011.04.032
  • Peer Reviewed
• [Journal Article] Suppression mechanism of the photodegradation of J-aggregate thin films of cyanine dyes by coating withpolysilanes (2011)
  • Author(s): H. Horiuchi, S. Ishida, K. Matsuzaki, K. Tani, T. Hashimoto, H. Hotta, K. Tsunoda, T. Kodaira, T. Okutsu, H. Hiratsuka
  • Journal Title: J. Phys. Chem. C Volume: 115 Issue: 14 Pages: 6902-6909
  • DOI: 10.1021/jp109510x
  • Peer Reviewed
• [Journal Article] Singlet molecular oxygen generation by water-soluble phthalocyanine dendrimers with different aggregation behavior (2011)
  • Author(s): M. Nishida, H. Horiuchi, A. Momotake, Y. Nishimura, H. Hiratsuka, T. Arai
  • Journal Title: J. Porphyr. Phthalocyanines Volume: 15 Issue: 01 Pages: 47-53
  • DOI: 10.1142/s1088424611003008
  • Peer Reviewed
• [Journal Article] Protein Crystallization Induced by Strong Photons-molecules Coupling Fields Photochemical Reaction (2011)
  • Author(s): Susumu Haruta
  • Journal Title: J. Photochem. Photobiol. A: Chem. Volume: 221 Issue: 2-3 Pages: 268-272
  • DOI: 10.1016/j.jphotochem.2011.03.012
  • Peer Reviewed
• [Journal Article] Evidencefor the Specific Species of Benzyltriethoxysilane Derivatives with a High-coordination Silicon Atom
  • Author(s): H. Hiratsuka, H. Horiuchi, T. Kudo, T. Minegish, A. Yonemoto, N. Kusakari, T. Okutsu, N. Kamiyama, S. Murakami
  • Journal Title: J. Phys. Chem. A Volume: (in press)
  • Peer Reviewed
• [Presentation] Development of Silyl-photosensitizing Drug for Photodynamic Therapy (2013)
  • Author(s): H. Horiuchi
  • Organizer: 日本化学会第93 春 季年会 Asia International Symposium: Photochemistry Division(招待講演)
  • Place of Presentation: 草津
  • Year and Date: 2013-03-24
• [Presentation] Development of Silyl-photosensitizing Drug for Photodynamic Therapy (2013)
  • Author(s): Hiroaki HORIUCHI
  • Organizer: 日本化学会第93春季年会 Asia International Symposium: Photochemistry Division
  • Place of Presentation: 草津
  • Invited
• [Presentation] シリル基を導入したポルフィリン類の近赤外領域における吸収特性の改善 (2013)
  • Author(s): 秋山真吾・堀内宏明・伊藤智志・奥津哲夫・飛田成史・吉原利忠
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 草津
• [Presentation] 光開裂性脂質を用いたナノカーボンの可溶化、及び光凝集 (2013)
  • Author(s): 竹内直也・堀内宏明・田中秀和・上原宏樹・山延健・奥津哲夫
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 草津
• [Presentation] シリルポルフィリンの光線力学作用に及ぼす中心金属の効果 (2012)
  • Author(s): 堀内宏明・寺嶋慶介・奥津哲夫・平塚浩士
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 神奈川
  • Year and Date: 2012-03-26
• [Presentation] Improvements of Light Absorption Efficiency of Silyl-photosensitizing Drug forPhotodynamic Therapy (2012)
  • Author(s): H. Horiuchi, R. Ikeda, S. Akiyama,S. Ito, Y. Gomibuchi, Y. Saito, M. Hosaka, T. Okutsu
  • Organizer: 4th Asian Silicon Symposium
  • Place of Presentation: Tsukuba
• [Presentation] Improvements of Silyl-photosensitizing Drug for Photodynamic Therapy (2012)
  • Author(s): H. Horiuchi, S. Akiyama, S. Ito, Y. Saito, M. Hosaka, T. Okutsu
  • Organizer: 2nd InternationalSymposium on Element Innovation
  • Place of Presentation: Kiryu
• [Presentation] 光線力学療法に用いるシリル光増感剤の吸収特性の改良 (2012)
  • Author(s): 堀内宏明・秋山真吾・池田玲美・伊藤智志・五味渕雄太・久新荘一郎・奥津哲夫
  • Organizer: 2012年光化学討論会
  • Place of Presentation: 東京
• [Presentation] 光増感剤の輸送体として作用する光崩壊性リポソームの研究 (2012)
  • Author(s): 福田香奈、堀内宏明、山田圭一、奥津哲夫
  • Organizer: 2012年光化学討論会
  • Place of Presentation: 東京
• [Presentation] 光線力学療法に用いるシリル光増感色素の吸収特性の改良 (2012)
  • Author(s): 堀内 宏明・秋山 真吾・池田 玲美・伊藤 智志・五味渕 雄太・久新 荘一郎・奥津 哲夫
  • Organizer: 2012年光化学討論会
  • Place of Presentation: 東京
• [Presentation] Improvements of Silyl-photosensitizing Drug for Photodynamic Therapy (2012)
  • Author(s): Hiroaki Horiuchi, Shingo Akiyama, Satoshi Ito, Yuki Saito, Masahiro Hosaka, Tetsuo Okutsu
  • Organizer: 2nd International Symposium on Element Innovation
  • Place of Presentation: Kiryu
• [Presentation] Improvements of Light Absorption Efficiency of Silyl-photosensitizing Drug for Photodynamic Therapy (2012)
  • Author(s): Hiroaki Horiuchi, Remi Ikeda, Shingo Akiyama, Satoshi Ito, Yuta Gomibuchi, Yuki Saito, Masahiro Hosaka, Tetsuo Okutsu
  • Organizer: 4th Asian Silicon Symposium
  • Place of Presentation: Tsukuba
• [Presentation] シリル基を導入したポルフィリン類の近赤外領域における吸収特性の改善 (2012)
  • Author(s): 秋山真吾・堀内宏明・伊藤智志・奥津哲夫
  • Organizer: 平成24年度日本化学会関東支部群馬地区地域懇談会
  • Place of Presentation: 前橋
• [Presentation] 光開裂性脂質を用いたナノカーボンの可溶化、及び光凝集 (2012)
  • Author(s): 竹内直也・堀内宏明・田中秀和・上原宏樹・山延健・奥津哲夫
  • Organizer: 平成24年度日本化学会関東支部群馬地区地域懇談会
  • Place of Presentation: 前橋
• [Presentation] Photochemically-induced Protein Crystallization (2012)
  • Author(s): T. Okutsu, T. Kuroiwa, K. Kobayashi, T.Taguchi, Y. Takase, S. Haruta, T. Yamashita, H. Imai, Y. Ishikawa, H. Horiuchi, H. Hiratsuka
  • Organizer: Japan-Netherlands Symposium on Crystal Growth -Theory and In-situ Measurements-: JaNe2012
  • Place of Presentation: Sendai
• [Presentation] Photochemically induced crystallization (2012)
  • Author(s): T. Okutsu, H. Ihira, T. Kuroiwa, S. Haruta, H. Horiuchi, H. Hiratsuka
  • Organizer: APC2012
  • Place of Presentation: Osaka
• [Presentation] A novel strategy of membrane protein crystallization in lipid (2012)
  • Author(s): H. Ihira, H. Takahashi, T. Kuroiwa, H. Horiuchi, T. Okutsu
  • Organizer: Japan-Netherlands Symposium on Crystal Growth -Theory and In-situ Measurements-: JaNe2012
  • Place of Presentation: Sendai
• [Presentation] 増感剤の輸送体として働く光崩壊性リポソームの研究 (2012)
  • Author(s): 福田香奈、堀内宏明、山田圭一、奥津哲夫
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 神奈川
• [Presentation] The effect of metal ion on the photodynamic activity of silylporphyrin (2011)
  • Author(s): H. Horiuchi, K. Terashima, T. Okutsu, H. Hiratsuka
  • Organizer: The First International Symposium on Element Inovation
  • Place of Presentation: Kiryu
  • Year and Date: 2011-12-09
• [Presentation] 光線力学療法に用いるケイ素光増感剤の研究 (2011)
  • Author(s): 堀内宏明・眞塩広之・福田香奈・穂坂正博・石田真太郎・久新荘一郎・竹内利行・奥津哲夫・平塚浩士
  • Organizer: 2011年光化学討論会
  • Place of Presentation: 宮崎
  • Year and Date: 2011-09-06
• [Presentation] The effect of metal ion on the photodynamic activity of silylporphyrin (2011)
  • Author(s): H. Horiuchi, K. Terashima, T. Okutsu, H. Hiratsuka
  • Organizer: The First International Symposium on Element Inovation
  • Place of Presentation: Kiryu, Japan
• [Presentation] ケイ素置換基による光増感色素の活性向上 (2011)
  • Author(s): 堀内宏明、眞塩広之、穂坂正博、石田真太郎、久新荘一郎、奥津哲夫、竹内利行、平塚浩士
  • Organizer: 第21回日本光線力学学会学術講演会
  • Place of Presentation: 大阪
• [Presentation] 光線力学療法に用いるケイ素光増感色素の研究 (2011)
  • Author(s): 堀内宏明・眞塩広之・福田香奈・穂坂正博・石田真太郎・久新荘一郎・竹内利行・奥津哲夫・平塚浩士
  • Organizer: 2011年光化学討論会
  • Place of Presentation: 宮崎
• [Presentation] シリル化ポルフィリンの光物性に及ぼす中心金属の効果 (2011)
  • Author(s): 寺嶋慶介、堀内宏明、眞塩広之、穂坂正博、竹内利行、石田真太郎、久新荘一郎、奥津哲夫、平塚浩士
  • Organizer: 2011年光化学討論会
  • Place of Presentation: 宮崎
• [Presentation] 光増感剤の輸送体としての光崩壊性リポソームの研究 (2011)
  • Author(s): 福田香奈、堀内宏明、山田圭一、 奥津哲夫
  • Organizer: 日本化学会第5回関東支部大会
  • Place of Presentation: 東京
• [Presentation] 光線力学療法に用いるシリルポルフィリンの開発 (2011)
  • Author(s): 寺嶋慶介、堀内宏明、池田玲美、伊藤智志、石田真太郎、久新荘一郎、奥津哲夫、平塚浩士
  • Organizer: 第15回ケイ素化学シンポジウム
  • Place of Presentation: 神戸
• [Presentation] クロロシランを用いたシリルポルフィリン誘導体の合成と光線力学療法への応用 (2011)
  • Author(s): 堀内宏明・眞塩広之・穂坂正博・竹内利行・奥津哲夫・平塚浩士
  • Organizer: 201１ ハロゲン利用ミニシンポジウム
  • Place of Presentation: 宇都宮
• [Presentation] 近赤外光によるオレフィン化合物の酸化開裂反応を利用した薬剤放出制御の研究 (2011)
  • Author(s): 秋山 真吾、堀内 宏明、奥津 哲夫
  • Organizer: 平成23年度日本化学会関東支部群馬地区地域懇談会
  • Place of Presentation: 桐生
• [Presentation] 光増感剤の輸送体となる光崩壊性リポソームの研究 (2011)
  • Author(s): 福田香奈、堀内宏明、山田圭一、奥津哲夫
  • Organizer: 平成23年度日本化学会関東支部群馬地区地域懇談会
  • Place of Presentation: 桐生
• [Patent(Industrial Property Rights)] 含ケイ素置換基を導入した一重項酸素 発生剤 (2012)
  • Inventor(s): 堀内宏明,平塚浩士,久新荘一郎,松本英之,田中統,谷克彦,佐藤健太,吉村公男
  • Industrial Property Rights Holder: 国立大学法人群馬大学
  • Filing Date: 2012-01-13