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Development of mucosal vaccine using membrane permeation nanoparticles

Research Project

Project/Area Number 23760754
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biofunction/Bioprocess
Research InstitutionYamaguchi University

Principal Investigator

TOORISAKA Eiichi  山口大学, 大学院・理工学研究科, 准教授 (40363543)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords粘膜ワクチン / エマルション / 界面活性剤 / ナノ粒子
Research Abstract

In this study, S/O/W emulsion was used as a vaccine carrier to induce immunity at the mucosal surface. When the S/O/W was administered into the abdominal cavity, the IgG level in blood increased gradually. This result indicates that the S/O/W emulsion has the potential to be useful for antigen delivery into the mucosal immune system. However, when the formulation was administered into the nasal cavity, the specific IgG level in the blood was not led. To overcome that problem, we assessed a modification of the emulsion droplets by using a mucoadhesive polymer. As a result, the induction of immunity was confirmed. It was expected that the modification of mucoadhesive polymers on an oil droplet surface could improve the uptake of antigens to the immune system.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Intestinal patches with an immobilized solid-in-oil formulation for oral protein delivery2012

    • Author(s)
      Eiichi Toorisaka, Kikumi Watanabe, Hiroshige Ono, Makoto Hirata, Noriho Kamiya, MasahiroGoto
    • Journal Title

      Acta Biomaterialia

      Volume: 8 Issue: 2 Pages: 653-658

    • DOI

      10.1016/j.actbio.2011.09.023

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] エマルション油水界面を利用した機能性微粒子の開発2012

    • Author(s)
      前田 歩,通阪栄一,平田 誠,神谷典穂,後藤雅宏
    • Organizer
      環境資源工学会129回例会
    • Place of Presentation
      山口大学(山口市)
    • Year and Date
      2012-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] エマルション油水界面を利用した機能性微粒子の開発2012

    • Author(s)
      通阪栄一
    • Organizer
      環境資源工学科会129回例会
    • Place of Presentation
      山口大学(山口)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 油水界面での細胞培養とタンパク質導入の検討2012

    • Author(s)
      野中友美,通阪栄一
    • Organizer
      化学工学会中四国支部大会
    • Place of Presentation
      サンポートホール高松(高松)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 有機-無機複合粒子による放出制御型製剤の開発2011

    • Author(s)
      古賀悠歩,通阪栄一,平田 誠
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学(文京区)
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗原デリバリーのための粘膜付着性微粒子の開発2011

    • Author(s)
      木村味加,通阪栄一,平田 誠,松本 昴,西園 晃,神谷典穂,後藤雅宏
    • Organizer
      第27回日本DD学会
    • Place of Presentation
      東京大学(文京区)
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 膜結合性集合体による動物細胞へのタンパク質導入2011

    • Author(s)
      前田 歩,通阪栄一,平田 誠,神谷典穂,後藤雅宏
    • Organizer
      第27回日本DD学会
    • Place of Presentation
      東京大学(文京区)
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 有機・無機複合粒子による放出制御型製剤の開発

    • Author(s)
      古賀 悠歩、通阪 栄一、平田 誠
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 抗原デリバリーのための粘膜付着性微粒子の開発

    • Author(s)
      木村 味加、通阪 栄一、平田 誠、松本 昴、西園 晃、神谷 典穂、後藤 雅宏
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 膜融合性集合体による動物細胞へのタンパク質導入

    • Author(s)
      前田 歩、通阪 栄一、平田 誠、神谷 典穂、後藤 雅宏
    • Organizer
      第27回日本DDS学会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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