Identifying the active form of FGF19 based on the fact that beta-Klotho recognizes a distinct sugar motif.
| Project/Area Number |
23770166
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | 公益財団法人先端医療振興財団 (2012)
Foundation for Biomedical Research and Innovation (2011) |
|---|
Principal Investigator |
MAEDA Ryota 公益財団法人先端医療振興財団, 先端医療センター, 研究員 (50432399)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IMURA Akihiro (60362513)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 細胞・組織 / シグナル伝達 / 生理活性 / 蛋白質 / 糖鎖 / 代謝 / 電解質 / レクチン / グルクロン酸修飾 / 線維芽細胞増殖因子 / ナトリウムカリウム輸送体 / クロトー |
|---|
| Research Abstract |
We have proposed that specific carbohydrate modifications play an important role in physiological activities of the endocrine fibroblast growth factors, including FGF-23, FGF 9, and FGF-21. Based on our previous study that a sugar modification increases activities of FGF-3, we tried to identify any modifications that enhance activities of other endocrine fibroblast growth factors, FGF-19 and FGF-21. Consequently, we show that a distinct terminal glucuronic acid sugar modification is sufficient for proper activity of these growth factors.
|
Report
(3 results)
Research Products
(36 results)
