Analysis of molecular function on DNA methylation regulator PGC7
| Project/Area Number |
23770224
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Nagahama Institute of Bio-Science and Technology |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | クロマチン / 受精卵 / DNA メチル化 / ヒストンメチル化 / DNAメチル化 / DNA / ヒストン / 脱メチル化 / メチル化 / PGC7 |
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| Research Abstract |
In this study, we found that 5-hydroxymethylcytosine (5hmC) accumulated in the paternal genome along the rapid disappearance of 5-methylcytosine (5mC). In addition, we revealed that PGC7 binds di-methylated histone H3K9 to protect against conversion of 5mC to 5hmC in maternal genome.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] GPAT2, a Mitochondrial Outer Membrane Protein in piRNA Biogenesis in Germline Stem Cells2013
Author(s)
Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T
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Journal Title
RNA
Volume: 19
Issue: 6
Pages: 803-810
DOI
Related Report
Peer Reviewed
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[Journal Article] PGC7 binds histone H3K9me2 to protect against conversion of 5MeC to 5HmC in early embryos2012
Author(s)
Nakamura, T., Liu, Y.U., Nakashima, H., Umehara, H., Inoue, K., Matoba, S., Tachibana, M., Ogura, A., Shinkai, Y., Nakano, T
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Journal Title
Nature
Volume: 486
Issue: 7403
Pages: 415-419
DOI
Related Report
Peer Reviewed
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[Presentation] Regulation of mouse brain development by DNA and histone methylation: From molecular basis to cognitive, behavioral, and motor abnormalities in gene-manipulated model mice2012
Author(s)
Taga T, Kagawa T, Bizen N, Yamaguchi Y, Kokubu Y, Hattori S, Takao K, Miyakawa T, Inazawa J, Nakamura T, Nakano T
Organizer
The 35th Annual Meeting of the Japan Neuroscience Society, Symposium onEpigenetics and neuropsychiatric disorders
Place of Presentation
名古屋
Year and Date
2012-09-19
Related Report
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[Presentation] Epigenetic regulation of neural stem cell differentiation and brain development2012
Author(s)
Taga T, Kagawa T, Bizen N, Yamaguchi Y, Kokubu Y, Hattori S, Takao K, Miyakawa T, Inazawa J, Nakamura T, Nakano T
Organizer
ISSCR 10th Annual Meeting
Place of Presentation
淡路
Year and Date
2012-06-01
Related Report
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[Presentation] Epigenetic regulation of neural stem cell differentiation and brain development2012
Author(s)
Taga T, Kagawa T, Bizen N, Yamaguchi Y, Kokubu Y, Hattori S, Takao K, Miyakawa T, Inazawa J, Nakamura T, Nakano T
Organizer
ISSCR 10th Annual Meeting
Place of Presentation
Yokohama
Related Report
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[Presentation] Regulation of mouse brain development by DNA and histone methylation: From molecular basis to cognitive, behavioral, and motor abnormalities in gene-manipulated model mice2012
Author(s)
Taga T, Kagawa T, Bizen N, Yamaguchi Y, Kokubu Y, Hattori S, Takao K, Miyakawa T, Inazawa J, Nakamura T, Nakano T
Organizer
The 35th Annual Meeting of the Japan Neuroscience Society, Symposium on Epigenetics and neuropsychiatric disorders
Place of Presentation
Nagoya
Related Report
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