Study of the molecular mechanism of oxidative stress response induced by mitochondrial ROS
Project/Area Number |
23770227
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cell biology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 酸化ストレス / ミトコンドリア / 細胞内情報伝達 / 細胞死 / 線虫 / ヒト培養細胞 / 活性酸素 |
Research Abstract |
An experimental assay system was employed to generate excessive ROS in the mitochondria in a precisely controlled spatio-temporal manner. Using mammalian cells and worm C. elegans generating mitochondrial ROS, I analyzed the stress response and the molecular mechanism induced by mitochondrial ROS in vitro and in vivo. I revealed that factors involved in the mitochondrial permeability transition (Cyclophilin D and Ca++) were contributed to the mitochondrial oxidative stress response and that mitochondrial ROS affected the development of C.elegans.
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Report
(3 results)
Research Products
(7 results)