Regulatory mechanisms of actin cytoskeleton and cell adhesion by Wnt/planar cell polarity pathway core molecules

• Project/Area Number: 23770260
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental biology
• Research Institution: Osaka City University
• Principal Investigator: KAI Masatake 大阪市立大学, 大学院・医学研究科, 講師 (30572573)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 形態形成 / 細胞運動 / 細胞接着 / プロトカドヘリン / リン酸化 / ユビキチン化 / 分子機構 / 初期発生 / Wnt／平面細胞極性 / 細胞骨格

Research Abstract

In order to elucidate molecular mechanisms underling early morphogenesis, I investigated regulation of paraxial protocadherin (PAPC), which is supposed to control cell adhesion essential for grouped cell migration. I revealed that PAPC is phosphorylated a

Research Products

• [Journal Article] Myocardial progenitors in the pharyngeal regions migrate to distinct conotruncal regions (2012)
  • Author(s): Takahashi M, Terasako Y, Yanagawa N, Kai M, Yamagishi T, Nakajima Y
  • Journal Title: Dev Dyn Volume: 241 Issue: 2 Pages: 284-93
  • DOI: 10.1002/dvdy.23714
  • Peer Reviewed
• [Journal Article] Planar Cell Polarity in Coordinated and Directed Movements (2012)
  • Author(s): Tada M, Kai M
  • Journal Title: Current Topics in Developmental Biology Volume: 101 Pages: 77-110
  • DOI: 10.1016/b978-0-12-394592-1.00004-1
  • Peer Reviewed
• [Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation-dependent ubiquitinsystem is required for Xenopus early development (2013)
  • Author(s): 甲斐理武,木下典行
  • Organizer: 第46回日本発生生物学会
  • Place of Presentation: 松江
  • Year and Date: 2013-05-30
• [Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation-dependent ubiquitin system is required for Xenopus early development. (2013)
  • Author(s): 甲斐理武,木下典行
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-30
• [Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation-dependent ubiquitin system is required for Xenopus early development (2013)
  • Author(s): 甲斐理武，木下典行
  • Organizer: 第118回日本解剖学会全国学術集会
  • Place of Presentation: サンポートホール高松・かがわ国際会議場（香川県高松市）
• [Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation-dependent ubiquitin system is required for Xenopus early development. British Society for Developmental Biology (2012)
  • Author(s): Kai M, Kinoshita N
  • Organizer: British Society for Cell Biology and Japanese Society of Developmental Biologists Joint Spring Meeting
  • Place of Presentation: University of Warwick, UK
  • Year and Date: 2012-04-17
• [Presentation] Regulation of paraxial protocadherin (PAPC) by a phosphorylation-dependent ubiquitin system is required for Xenopus early development (2012)
  • Author(s): Kai M, Kinoshita N
  • Organizer: BSCB/BSDB/JSDB Joint Spring Meeting
  • Place of Presentation: University of Warwick, UK
• [Presentation] 初期発生におけるユビキチン化を介した細胞接着分子の制御機構 (2011)
  • Author(s): 甲斐理武
  • Organizer: 日本発生生物学会秋期シンポジウム2011
  • Place of Presentation: 岡崎
  • Year and Date: 2011-12-21
• [Presentation] Prickle and β-TrCP regulate cell adhesion by controllingparaxial protocadherin activity through ubiquitination in Xenopus development (2011)
  • Author(s): 甲斐理武,木下典行
  • Organizer: 第44回日本発生生物学会
  • Place of Presentation: 宜野湾
  • Year and Date: 2011-05-19
• [Presentation] Prickle and beta-TrCP regulate cell adhesion by controlling paraxial protocadherin activity through ubiquitination in Xenopus development
  • Author(s): 甲斐理武，木下典行
  • Organizer: 44th Annual Meeting of the Japanese Society of Developmental Biologists
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県）
• [Presentation] 初期発生におけるユビキチン化を介した細胞接着分子の制御機構
  • Author(s): 甲斐理武
  • Organizer: 日本発生生物学会 秋期シンポジウム２０１１
  • Place of Presentation: 岡崎コンファレンスセンター（愛知県）