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Second messenger systems required for epithelial morphogenesis in vivo

Research Project

Project/Area Number 23770261
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental biology
Research InstitutionNational Institute for Basic Biology

Principal Investigator

SUZUKI Makoto  基礎生物学研究所, 形態形成研究部門, 助教 (10533193)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経管閉鎖 / 頂端収縮 / カルシウム / 神経管 / 上皮 / セカンドメッセンジャー / 細胞・組織 / 発生・分化
Research Abstract

To understand function and regulatory mechanism of second messenger systems in epithelial morphogenesis in vivo, we performed cell biological analyses of neural tube formation in Xenopus and zebrafish embryos. Results presented here showed that intracellular calcium ion signaling positively regulates apical constriction, one of the important cellular behaviors in the neuroepithelial cells. We also found that extracellular ATP was involved in calcium-mediated apical constriction. These findings would help us to understand pathological mechanisms of various disorders in human, resulted from the abnormalities in epithelial tissues.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Left-right asymmetry is formed in individual cells by intrinsic cell chirality2014

    • Author(s)
      Hatori, R., Ando, T., Sasamura, T., Nakazawa, N., Nakamura, M., Taniguchi, K., Hozumi, S., Kikuta, J., Ishii, M., *Matsuno, K.
    • Journal Title

      Mech Dev

      Volume: 133 Issue: 2 Pages: 482-95

    • DOI

      10.1016/j.ydbio.2013.07.023

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transgenic Xenopus laevis for live imaging in cell and developmental biology.2013

    • Author(s)
      Takagi, C., Sakamaki, K., Morita, H., Hara, Y., Suzuki, M., Kinoshita, N. and Ueno, N.
    • Journal Title

      Development, Growth & Differentiation

      Volume: 55 Issue: 4 Pages: 422-433

    • DOI

      10.1111/dgd.12042

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Translation of incenp during oocyte maturation is required for embryonic development in Xenopus laevis2012

    • Author(s)
      GG Leblond, H Sarazin, R Li, M Suzuki, N Ueno, XJ Liu
    • Journal Title

      Biology of reproduction

      Volume: 86 Issue: 5 Pages: 161-161

    • DOI

      10.1095/biolreprod.111.097972

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of cell shape changes that contribute to vertebrate neural tube closure2012

    • Author(s)
      Makoto Suzuki
    • Journal Title

      Development, Growth & Differentiation

      Volume: 54 Issue: 3 Pages: 266-276

    • DOI

      10.1111/j.1440-169x.2012.01346.x

    • NAID

      10031136900

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ゼブラフィッシュ神経管における周期的な収斂運動2014

    • Author(s)
      鈴木誠
    • Organizer
      平成25年度日本動物学会中部支部大会
    • Place of Presentation
      岡﨑コンファレンスセンター(愛知県)
    • Year and Date
      2014-03-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 上皮性器官の形成における細胞と細胞骨格の動態に関する研究2014

    • Author(s)
      鈴木誠
    • Organizer
      生命情報科学若手の会第5回研究会
    • Place of Presentation
      東京大学検見川セミナーハウス(千葉県)
    • Year and Date
      2014-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Periodic contraction of actomyosin network during convergence movements in zebrafish neurulation2013

    • Author(s)
      鈴木誠
    • Organizer
      第19回小型魚類研究会
    • Place of Presentation
      仙台市情報・産業プラザ(宮城県)
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 上皮性器官の形態形成を支える細胞と細胞骨格の動態の制御2013

    • Author(s)
      鈴木誠
    • Organizer
      第53回生物物理若手の会夏の学校
    • Place of Presentation
      伊豆長岡温泉えふでの宿小松家八の坊(静岡県)
    • Year and Date
      2013-09-08
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Periodic contraction of actomyosin network during convergence movements in zebrafish neurulation2013

    • Author(s)
      鈴木誠
    • Organizer
      8th European Zebrafish Meeting
    • Place of Presentation
      Palau de Congressos de Catalunya (Spain)
    • Year and Date
      2013-07-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Control of apical constriction by dynamic calcium signaling during Xenopus neural tube closure2013

    • Author(s)
      鈴木誠
    • Organizer
      17th International Congress of Developmental Biology
    • Place of Presentation
      Cancun Convention Center (Mexico)
    • Year and Date
      2013-06-16
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 上皮性器官の形態形成を支える細胞と細胞骨格の動態の制御2013

    • Author(s)
      鈴木誠
    • Organizer
      第53回 生物物理若手の会 夏の学校
    • Place of Presentation
      伊豆長岡温泉 えふでの宿 小松家八の坊 (静岡県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Periodic contraction of actomyosin network during convergence movements in zebrafish neurulation2013

    • Author(s)
      鈴木誠
    • Organizer
      第19回 小型魚類研究会
    • Place of Presentation
      仙台市情報・産業プラザ (宮城県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The role of intracellular calcium signaling in apical constriction during Xenopus neural tube closure2012

    • Author(s)
      鈴木誠
    • Organizer
      日本発生生物学会第45回大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-05-30
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 脊椎動物の神経管にみる細胞の挙動とその制御機構2012

    • Author(s)
      鈴木誠
    • Organizer
      定量生物学の会第4回年会
    • Place of Presentation
      名古屋大学野依記念学術交流館(愛知県)
    • Year and Date
      2012-01-08
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of intracellular calcium signaling in apical constriction during Xenopus neural tube closure2012

    • Author(s)
      Makoto Suzuki
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会 合同大 会発生学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Spatio-temporal pattern of non-muscle myosin II activity in zebrafish neurulation2011

    • Author(s)
      鈴木誠
    • Organizer
      日本発生生物学会第44回大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2011-05-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ゼブラフィッシュ神経管形成における非筋型ミオシンの時空間分布2011

    • Author(s)
      鈴木 誠
    • Organizer
      発生生物学会 第44回大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Related Report
      2011 Research-status Report
  • [Book] Neural Tube Closure in Xenopus2014

    • Author(s)
      H Morita, M Suzuki, N Ueno
    • Publisher
      Xenopus Development
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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