Second messenger systems required for epithelial morphogenesis in vivo
Project/Area Number |
23770261
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
|
Research Institution | National Institute for Basic Biology |
Principal Investigator |
SUZUKI Makoto 基礎生物学研究所, 形態形成研究部門, 助教 (10533193)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 神経管閉鎖 / 頂端収縮 / カルシウム / 神経管 / 上皮 / セカンドメッセンジャー / 細胞・組織 / 発生・分化 |
Research Abstract |
To understand function and regulatory mechanism of second messenger systems in epithelial morphogenesis in vivo, we performed cell biological analyses of neural tube formation in Xenopus and zebrafish embryos. Results presented here showed that intracellular calcium ion signaling positively regulates apical constriction, one of the important cellular behaviors in the neuroepithelial cells. We also found that extracellular ATP was involved in calcium-mediated apical constriction. These findings would help us to understand pathological mechanisms of various disorders in human, resulted from the abnormalities in epithelial tissues.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Left-right asymmetry is formed in individual cells by intrinsic cell chirality2014
Author(s)
Hatori, R., Ando, T., Sasamura, T., Nakazawa, N., Nakamura, M., Taniguchi, K., Hozumi, S., Kikuta, J., Ishii, M., *Matsuno, K.
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Journal Title
Mech Dev
Volume: 133
Issue: 2
Pages: 482-95
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Transgenic Xenopus laevis for live imaging in cell and developmental biology.2013
Author(s)
Takagi, C., Sakamaki, K., Morita, H., Hara, Y., Suzuki, M., Kinoshita, N. and Ueno, N.
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Journal Title
Development, Growth & Differentiation
Volume: 55
Issue: 4
Pages: 422-433
DOI
Related Report
Peer Reviewed
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