Novel Role of mitotic cell rounding in epithelial invagination
| Project/Area Number |
23770264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KONDO Takefumi 独立行政法人理化学研究所, 形態形成シグナル研究グループ, 基礎科学特別研究員 (60565084)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 上皮形態形成 / 細胞分裂 / 分裂期球形化 / ショウジョウバエ / M期細胞球形化 / 上皮組織陥入 / 気管原基 / ライブ観察 |
|---|
| Research Abstract |
Animal cells change their shape into sphere upon mitotic entry. In this study, we revealed a novel active role of mitotic cell rounding in epithelial invagination of the Drosophila tracheal placode. Mitotic rounding, but not cell division, of the central cells in the placode is required to accelerate invagination, in conjunction with centripetal pressure from the surrounding cells. These results indicate that mitotic rounding regulates the epithelial tissue morphogenesis independent of its role in cell division.
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Report
(3 results)
Research Products
(26 results)
