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Novel Role of mitotic cell rounding in epithelial invagination

Research Project

Project/Area Number 23770264
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KONDO Takefumi  独立行政法人理化学研究所, 形態形成シグナル研究グループ, 基礎科学特別研究員 (60565084)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords上皮形態形成 / 細胞分裂 / 分裂期球形化 / ショウジョウバエ / M期細胞球形化 / 上皮組織陥入 / 気管原基 / ライブ観察
Research Abstract

Animal cells change their shape into sphere upon mitotic entry. In this study, we revealed a novel active role of mitotic cell rounding in epithelial invagination of the Drosophila tracheal placode. Mitotic rounding, but not cell division, of the central cells in the placode is required to accelerate invagination, in conjunction with centripetal pressure from the surrounding cells. These results indicate that mitotic rounding regulates the epithelial tissue morphogenesis independent of its role in cell division.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (21 results) (of which Invited: 1 results) Remarks (4 results)

  • [Journal Article] Mitotic cell rounding accelerates epithelial invagination.2013

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Journal Title

      Nature

      Volume: 494 Pages: 125-129

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode2013

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      CDB meeting
    • Place of Presentation
      RIKEN CDB, 兵庫県 神戸市
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode2013

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      CDB meeting
    • Place of Presentation
      RIKEN CDB, 兵庫県 神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 形態形成の現場を捉える -ショウショウハエ気管原基陥入を例にして-2012

    • Author(s)
      近藤武史
    • Organizer
      第五回evo-devo 青年の会
    • Place of Presentation
      基礎生物学研究所 愛知県 岡崎市
    • Year and Date
      2012-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic cell rounding accelerates epithelial invagination2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      The 10th Japanese Drosophila Research Conference
    • Place of Presentation
      The Jikei University School of Medicine 東京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic cell rounding accelerates epithelial invagination2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      Exciting Biologies Forces in biology
    • Place of Presentation
      the Herbert Park Hotel, Dublin, Ireland
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Mitotic cell rounding accelerates epithelial invagination2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      EMBO Conference Series Morphogenesis and Dynamics of Multicellular systems
    • Place of Presentation
      EMBL Heidelberg, Germany
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      Kobe International Conference Center The Kobe Chamber of Commerce and Industry 兵庫県神戸市
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      CDB Symposium2012
    • Place of Presentation
      RIKEN CDB (兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      53rd Annual Drosophila Research Conference
    • Place of Presentation
      Sheraton Chicago Hotel & Towers, Chicago, UAS
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Mitotic cell rounding accelerates invagination of the Drosophila tracheal placode2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      Kobe International Conference Center The Kobe Chamber of Commerce and Industry 兵庫県神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mitotic cell rounding accelerates epithelial invagination2012

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      The 10th Japanese Drosophila Research Conference
    • Place of Presentation
      The Jikei University School of Medicine 東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2012

    • Author(s)
      Takefumi Kondo, Shigeo Hayashi
    • Organizer
      CDB Symposium 2012
    • Place of Presentation
      RIKEN CDB (兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      ハシフィコ横浜(神奈川県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode,2011

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      Exciting Biology Series Cellular Development: Biology at the interface
    • Place of Presentation
      RIKEN CDB(兵庫県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      1st Asia- Pacific Drosophila Research Conference
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo and Shigeo Hayashi
    • Organizer
      44th Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Okinawa Convention Center(沖縄県)
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo, Shigeo Hayashi
    • Organizer
      44th Annual Meeting for the Japanese Society of Developmental Biologists
    • Place of Presentation
      Okinawa Convention Center(沖縄県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo, Shigeo Hayashi
    • Organizer
      1st Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      Chientan Youth Activity Center, Taipei, Taiwan
    • Related Report
      2011 Research-status Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo, Shigeo Hayashi
    • Organizer
      Exciting Biology Series Cellular Development: Biology at the interface
    • Place of Presentation
      RIKEN CDB(兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Mitotic Cell Rounding Accelerates Invagination of the Drosophila Tracheal Placode2011

    • Author(s)
      Takefumi Kondo, Shigeo Hayashi
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 形態形成の現場を捉える -ショウジョウバエ気管原基陥入を例にして-

    • Author(s)
      近藤武史
    • Organizer
      第五回evo-devo青年の会
    • Place of Presentation
      基礎生物学研究所 愛知県 岡崎市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 細胞分裂か組織陥入の引き金をひく

    • URL

      http://www.cdb.riken.jp/jp/04_news/articles/13/130125_invagination.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 組織形成における細胞分裂の新しい役割の発見

    • URL

      http://www.riken.jp/pr/press/2013/20130114_1/

    • Related Report
      2012 Final Research Report
  • [Remarks] 細胞分裂が組織陥入の引き金をひく

    • URL

      http://www.cdb.riken.jp/jp/04_news/articles/13/130125_invagination.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] 組織形成における細胞分裂の新しい役割の発見

    • URL

      http://www.riken.jp/pr/press/2013/20130114_1/

    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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