Elucidation of cell position-dependent Hippo-pathway regulatorymechanisms in preimplantation embryos
Project/Area Number |
23770265
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
|
Research Institution | Kumamoto University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 細胞分化 / Hippo 経路 / 細胞接着 / Angiomotin / カドヘリン / カテニン / マウス / 着床前 / Hippo経路 / 着床前胚 / 発生生物学 |
Research Abstract |
Hippo signaling in preimplantation embryos exhibits a cellposition-dependent difference in strength. Inner and outer cells show strong and weaksignaling, respectively. This research clarified the mechanisms of the Hippo pathwayactivation by an adhesion-associated protein Angiomotin and its suppression by cellpolarity. This is the machinery which converts cell position into differential strengthof Hippo signaling. This research uncovered a key problem of the Hippo pathway regulation,which contributes to the progress of the relevant fields
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Report
(3 results)
Research Products
(11 results)