| Project/Area Number |
23780123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Osaka Electro-Communication University |
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Principal Investigator |
SAITH Akiko 大阪電気通信大学, 工学部, 准教授 (40415162)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 生物活性物質 / 化学生物学 / proanthocyanidins / polyphenols / bioprobe / SAR / biological activity / chemical biology / proanthocyanidin / polyphenol / regioselective synthesis |
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| Research Abstract |
Proanthocyanidins (PAs), which have various strong biological activities, were modified with fluorescent molecules, fluorous tags, etc. by using our regioselective deprotection method for chemical biological studies of PAs. Using fluorous tags, the interaction between PAs and recombinant DNA polymerase ? was detected with SDS page. Furthermore, we identified that 3,3’’-digallate dimers showed extremely high activity against decrease in cell proliferation (HeLa S3). However, the effect of oligosaccharides for stabilization of PAs was not detected with antioxidant activity.
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