| Project/Area Number |
23780127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Makoto 東京大学, 大学院・農学生命科学研究科, 助教 (40409008)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | TGR5 / 胆汁酸 / 肥満 / 機能性食品 / GPCR / 食品 / 糖尿病 |
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| Research Abstract |
TGR5 is a member of G protein-coupled receptor which is activated by bile acids, and has been reported its anti-obese and anti-diabetic effects. The screening experiments using food factor library identified some food factors, including nomilin, activate TGR5. From animal studies, we found that nomilin improved high fat diet-induced obesity and hyperglycemia, suggesting nomilin may contribute to an improvement of metabolic syndrome. We also found that another food factor (factor A), which activates TGR5, decreased body weight gain by high fat diet.
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