Experimental study on induction of anti-virus antibody producing cells into the brain
| Project/Area Number |
23780306
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied veterinary science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SUNDEN Yuji 北海道大学, 大学院・獣医学研究科, 助教 (20451403)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 病理学 / 抗体 / ウイルス / 中枢神経系 / 神経細胞 / ケモカイン / 人獣共通感染症 / 狂犬病 / 抗体産生細胞 / 脳内免疫 |
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| Research Abstract |
The objective of the present study is to establish an effective prophylactic/therapeutic measure against neurotropic virus infections, rabies and/or pseudorabies. By using experimental animals, an induction of anti-virus antibody producing cells from peripheral tissues into central nervous system (CNS) was tested. It is demonstrated that an induction of antibody-secreting cells into the CNS is partly mediated by chemokine CXCL12 expression. Further, the induction of anti-virus antibodies into CNS is effective for inhibition of virus propagation, especially for rabies virus, in mice experiment.
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Report
(3 results)
Research Products
(14 results)
