Basic research on establishing of novel diagnosis and therapy using ADAMTS13 in dog with thrombosis.
| Project/Area Number |
23780327
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ADAMTS13 / 犬 / 血栓症 |
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| Research Abstract |
Human VWF73 is cleaved by canine ADAMTS13. And the decapeptide of the C-terminal edge of human VWF cleaved by canine ADAMTS13 is recognized by the anti-N10 antibody. Therefore the human ADAMTS13 activity ELISA kit, which consists of human VWF73 and anti-N10 antibody, could be applicable for measurement of plasma ADAMTS13 activity in dogs. Furthermore the ADAMTS13 activity in dogs with bacteremia was significantly lower than that in healthy dogs.
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Report
(3 results)
Research Products
(4 results)
